Estrogen related receptor
- Estrogen related receptor
protein
Name=estrogen-related receptor alpha
caption=
width=
HGNCid=3471
Symbol=ESRRA
AltSymbols=ESRL1
EntrezGene=2101
OMIM=601998
RefSeq=NM_004451
UniProt=P11474
PDB=
ECnumber=
Chromosome=11
Arm=q
Band=12
LocusSupplementaryData=protein
Name=estrogen-related receptor beta
caption=
width=
HGNCid=3473
Symbol=ESRRB
AltSymbols=ESRL2
EntrezGene=2103
OMIM=602167
RefSeq=NM_004452
UniProt=O95718
PDB=
ECnumber=
Chromosome=14
Arm=q
Band=24.3
LocusSupplementaryData=protein
Name=estrogen-related receptor gamma
caption=
width=
HGNCid=3474
Symbol=ESRRG
AltSymbols=
EntrezGene=2104
OMIM=602969
RefSeq=NM_206595
UniProt=P62508
PDB=
ECnumber=
Chromosome=1
Arm=q
Band=41
LocusSupplementaryData= There are three known estrogen related receptors:
* ERRα (gene|ESRRA)
* ERRβ (gene|ESRRB)
* ERRγ (gene|ESRRG)
The ERRs are members of the orphan nuclear receptor family.
ERR's bind to estrogen response elements on DNA and modulate transcription but do not bind to endogenous estrogens.
In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer.[cite journal |author=Ariazi E, Jordan V |title=Estrogen-related receptors as emerging targets in cancer and metabolic disorders |journal=Curr Top Med Chem |volume=6 |issue=3 |pages=203–15 |year=2006 |pmid=16515477 |doi=10.2174/156802606776173483] ]References
External links
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