- HOXD10
Homeobox D10, also known as HOXD10, is a human
gene .cite web | title = Entrez Gene: HOXD10 homeobox D10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3236| accessdate = ]PBB_Summary
section_title =
summary_text = This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.cite web | title = Entrez Gene: HOXD10 homeobox D10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3236| accessdate = ]ee also
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Homeobox References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tabin CJ |title=Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs. |journal=Development |volume=116 |issue= 2 |pages= 289–96 |year= 1993 |pmid= 1363084 |doi=
*cite journal | author=Goodman FR |title=Limb malformations and the human HOX genes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256–65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776
*cite journal | author=Redline RW, Williams AJ, Patterson P, Collins T |title=Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. |journal=Genomics |volume=13 |issue= 2 |pages= 425–30 |year= 1992 |pmid= 1351871 |doi=
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=Zappavigna V, Renucci A, Izpisúa-Belmonte JC, "et al." |title=HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. |journal=EMBO J. |volume=10 |issue= 13 |pages= 4177–87 |year= 1992 |pmid= 1756725 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Peverali FA, D'Esposito M, Acampora D, "et al." |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61–9 |year= 1991 |pmid= 1981366 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Guazzi S, Lonigro R, Pintonello L, "et al." |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=
*cite journal | author=Redline RW, Hudock P, MacFee M, Patterson P |title=Expression of AbdB-type homeobox genes in human tumors. |journal=Lab. Invest. |volume=71 |issue= 5 |pages= 663–70 |year= 1994 |pmid= 7967520 |doi=
*cite journal | author=Wulfsberg EA, Mirkinson LJ, Meister SJ |title=Autosomal dominant tetramelic postaxial oligodactyly. |journal=Am. J. Med. Genet. |volume=46 |issue= 5 |pages= 579–83 |year= 1993 |pmid= 8100684 |doi= 10.1002/ajmg.1320460524
*cite journal | author=Osborne J, Hu C, Hawley C, "et al." |title=Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma. |journal=J. Soc. Gynecol. Investig. |volume=5 |issue= 5 |pages= 277–80 |year= 1998 |pmid= 9773404 |doi=
*cite journal | author=Del Campo M, Jones MC, Veraksa AN, "et al." |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=
*cite journal | author=Shanmugam K, Green NC, Rambaldi I, "et al." |title=PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7577–88 |year= 1999 |pmid= 10523646 |doi=
*cite journal | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=
*cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509–22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001
*cite journal | author=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547–55 |year= 2002 |pmid= 11778160 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009External links
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PBB_Controls
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