OLIG1

Oligodendrocyte transcription factor 1
Identifiers
Symbols	OLIG1; BHLHB6; BHLHE21
External IDs	OMIM: 606385 MGI: 1355334 HomoloGene: 9667 GeneCards: OLIG1 Gene
Gene Ontology Molecular function • DNA binding Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • multicellular organismal development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116448	50914
Ensembl	ENSG00000184221	ENSMUSG00000046160
UniProt	Q8TAK6	Q3TY96
RefSeq (mRNA)	NM_138983	NM_016968.4
RefSeq (protein)	NP_620450	NP_058664.2
Location (UCSC)	Chr 21: 34.44 – 34.44 Mb	Chr 16: 91.27 – 91.27 Mb
PubMed search	[1]	[2]

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.^[1][2]

References

1. ^ Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proc Natl Acad Sci U S A 98 (19): 10851–6. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=58563. 
2. ^ "Entrez Gene: OLIG1 oligodendrocyte transcription factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116448. 

Further reading

• Zhou Q, Wang S, Anderson DJ (2000). "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors.". Neuron 25 (2): 331–43. doi:10.1016/S0896-6273(00)80898-3. PMID 10719889. 
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
• Takebayashi H, Yoshida S, Sugimori M, et al. (2001). "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.". Mech. Dev. 99 (1-2): 143–8. doi:10.1016/S0925-4773(00)00466-4. PMID 11091082. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• McLellan AS, Langlands K, Kealey T (2003). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.". Gene Expr. Patterns 2 (3-4): 329–35. doi:10.1016/S0925-4773(02)00390-8. PMID 12617822. 
• McLellan AS, Langlands K, Kealey T (2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.". Mech. Dev. 119 Suppl 1: S285–91. doi:10.1016/S0925-4773(03)00130-8. PMID 14516699. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Arnett HA, Fancy SP, Alberta JA, et al. (2005). "bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.". Science 306 (5704): 2111–5. doi:10.1126/science.1103709. PMID 15604411. 
• Jakovcevski I, Zecevic N (2006). "Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS.". J. Neurosci. 25 (44): 10064–73. doi:10.1523/JNEUROSCI.2324-05.2005. PMID 16267213. 
• Goris A, Yeo TW, Maranian M, et al. (2006). "Novel Olig 1-coding variants and susceptibility to multiple sclerosis.". J. Neurol. Neurosurg. Psychiatr. 77 (11): 1296–7. doi:10.1136/jnnp.2006.090639. PMC 2077377. PMID 16820418. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2077377. 
• Ruf N, Martelli M, Weschke B, Uhlenberg B (2007). "Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 365–6. doi:10.1002/ajmg.b.30434. PMID 17171653. 
• Brena RM, Morrison C, Liyanarachchi S, et al. (2007). "Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.". PLoS Med. 4 (3): e108. doi:10.1371/journal.pmed.0040108. PMC 1831740. PMID 17388669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1831740. 

External links

• MeSH OLIG1+protein,+human

(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP) (2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1 (2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655) (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains
(3.1) Homeodomain ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2)  · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B)  · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2) (3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) (3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4) (3.4) Heat Shock Factors HSF (1, 2, 4) (3.5) Tryptophan clusters ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2 (3.6) TEA domain transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5) (4.2) STAT STAT (1, 2, 3, 4, 5, 6) (4.3) p53 p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63 (4.4) MADS box Mef2 (A, B, C, D) · SRF (4.6) TATA binding proteins TBP · TBPL1 (4.7) High-mobility group BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4)  · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4) (4.10) Cold-shock domain CSDA, YBX1 (4.11) Runt CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors
(0.2) HMGI(Y) HMGA (1, 2) · HBP1 (0.3) Pocket domain Rb · RBL1 · RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 · EREBP · B3 (0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)