- SLC22A12
Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12, is a human
gene .cite web | title = Entrez Gene: SLC22A12 solute carrier family 22 (organic anion/cation transporter), member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116085| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: SLC22A12 solute carrier family 22 (organic anion/cation transporter), member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116085| accessdate = ]ee also
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Solute carrier family References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Hediger MA, Johnson RJ, Miyazaki H, Endou H |title=Molecular physiology of urate transport. |journal=Physiology (Bethesda, Md.) |volume=20 |issue= |pages= 125–33 |year= 2005 |pmid= 15772301 |doi= 10.1152/physiol.00039.2004
*cite journal | author=Enomoto A, Kimura H, Chairoungdua A, "et al." |title=Molecular identification of a renal urate anion exchanger that regulates blood urate levels. |journal=Nature |volume=417 |issue= 6887 |pages= 447–52 |year= 2002 |pmid= 12024214 |doi= 10.1038/nature742
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gisler SM, Pribanic S, Bacic D, "et al." |title=PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. |journal=Kidney Int. |volume=64 |issue= 5 |pages= 1733–45 |year= 2004 |pmid= 14531806 |doi= 10.1046/j.1523-1755.2003.00266.x
*cite journal | author=Ichida K, Hosoyamada M, Hisatome I, "et al." |title=Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. |journal=J. Am. Soc. Nephrol. |volume=15 |issue= 1 |pages= 164–73 |year= 2004 |pmid= 14694169 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Anzai N, Miyazaki H, Noshiro R, "et al." |title=The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 45942–50 |year= 2004 |pmid= 15304510 |doi= 10.1074/jbc.M406724200
*cite journal | author=Iwai N, Mino Y, Hosoyamada M, "et al." |title=A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. |journal=Kidney Int. |volume=66 |issue= 3 |pages= 935–44 |year= 2004 |pmid= 15327384 |doi= 10.1111/j.1523-1755.2004.00839.x
*cite journal | author=Takahashi T, Tsuchida S, Oyamada T, "et al." |title=Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese. |journal=Pediatr. Nephrol. |volume=20 |issue= 5 |pages= 576–8 |year= 2005 |pmid= 15772829 |doi= 10.1007/s00467-005-1830-z
*cite journal | author=Taniguchi A, Urano W, Yamanaka M, "et al." |title=A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout. |journal=Arthritis Rheum. |volume=52 |issue= 8 |pages= 2576–7 |year= 2005 |pmid= 16059895 |doi= 10.1002/art.21242
*cite journal | author=Shima Y, Teruya K, Ohta H |title=Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. |journal=Life Sci. |volume=79 |issue= 23 |pages= 2234–7 |year= 2006 |pmid= 16920156 |doi= 10.1016/j.lfs.2006.07.030
*cite journal | author=Ohtsuka Y, Zaitsu M, Ichida K, "et al." |title=Human uric acid transporter 1 gene analysis in familial renal hypo-uricemia associated with exercise-induced acute renal failure. |journal=Pediatrics international : official journal of the Japan Pediatric Society |volume=49 |issue= 2 |pages= 235–7 |year= 2007 |pmid= 17445045 |doi= 10.1111/j.1442-200X.2007.02337.xPBB_Controls
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