- Hypouricemia
Infobox_Disease
Name = PAGENAME
Caption =Uric acid
DiseasesDB = 21432
ICD10 =
ICD9 =
ICDO =
OMIM =
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MeshID =Hypouricemia is a condition where the level of
uric acid is below a certain threshold (between 2 mg/dL and 4 mg/dL, according to different sources.) The upper end of the normal range is 530 micromol/L (6 mg/dL) for women and 619 micromol/L (7 mg/dL) for men. cite journal |author=Chizyński K, Rózycka M |title= [Hyperuricemia] |language=Polish |journal=Pol. Merkur. Lekarski |volume=19 |issue=113 |pages=693–6 |year=2005 |month=November |pmid=16498814 |doi= |url=]Associated conditions
Hypouricemia is associated with several conditions, including:
*
Hyperthyroidism
*Nephritis
*Fanconi syndrome
*Wilson's disease
*Myeloma
*Multiple Sclerosis cite journal |author=Toncev G, Milicic B, Toncev S, Samardzic G |title=Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction |journal=Eur. J. Neurol. |volume=9 |issue=3 |pages=221–6 |year=2002 |month=May |pmid=11985629 |doi= |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1351-5101&date=2002&volume=9&issue=3&spage=221]Half of the cases can be associated with drugs (
allopurinol ) and toxic agents. Uric acid clearance should also be performed, increase in clearance points to proximal tubular defects in the kidney, normal or reduced clearance points to a defect in xanthine oxidase.It can also be associated with
total parenteral nutrition . cite journal |author=Koretz RL |title=Hypouricemia--a transient biochemical phenomenon of total parenteral nutrition |journal=Am. J. Clin. Nutr. |volume=34 |issue=11 |pages=2493–8 |year=1981 |month=November |pmid=6795918 |doi= |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=6795918]Vegetarian diet has been found to result in mean serum uric acid values as low as 239 micromol/L (2.7 mg/dL).cite journal |author=Szeto YT, Kwok TC, Benzie IF |title=Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk |journal=Nutrition |volume=20 |issue=10 |pages=863–6 |year=2004 |month=October |pmid=15474873 |doi=10.1016/j.nut.2004.06.006 |url=http://linkinghub.elsevier.com/retrieve/pii/S0899900704001674] While a vegetarian diet is typically seen as beneficial with respect to conditions such as gout,cite journal |author=Szeto YT, Kwok TC, Benzie IF |title=Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk |journal=Nutrition |volume=20 |issue=10 |pages=863–6 |year=2004 |month=October |pmid=15474873 |doi=10.1016/j.nut.2004.06.006 |url=http://linkinghub.elsevier.com/retrieve/pii/S0899900704001674] care should be taken to avoid hypouricemia and associated health conditions.
A specific condition,
Dalmatian hypouricemia , is known to have a genetic component. [OMIM|220150]In one study, hypouricemia was found in 4.8% of hospitalized women and 6.5% of hospitalized men. (The definition was less than 0.14 mmol l-1 for women and less than 0.20 mmol l-1 in men.) cite journal |author=Crook M |title=Hypouricaemia in a hospital population |journal=Scand. J. Clin. Lab. Invest. |volume=53 |issue=8 |pages=883–5 |year=1993 |month=December |pmid=8140400 |doi= |url=]
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