HOXB8

Homeobox B8, also known as HOXB8, is a human gene.cite web | title = Entrez Gene: HOXB8 homeobox B8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.cite web | title = Entrez Gene: HOXB8 homeobox B8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Peverali FA, D'Esposito M, Acampora D, "et al." |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61–9 |year= 1991 |pmid= 1981366 |doi=
*cite journal | author=Giampaolo A, Acampora D, Zappavigna V, "et al." |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Vider BZ, Zimber A, Hirsch D, "et al." |title=Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 3 |pages= 742–8 |year= 1997 |pmid= 9126347 |doi= 10.1006/bbrc.1997.6364
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Fujino T, Yamazaki Y, Largaespada DA, "et al." |title=Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. |journal=Exp. Hematol. |volume=29 |issue= 7 |pages= 856–63 |year= 2001 |pmid= 11438208 |doi=
*cite journal | author=Knoepfler PS, Sykes DB, Pasillas M, Kamps MP |title=HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. |journal=Oncogene |volume=20 |issue= 39 |pages= 5440–8 |year= 2001 |pmid= 11571641 |doi= 10.1038/sj.onc.1204710
*cite journal | author=Greer JM, Capecchi MR |title=Hoxb8 is required for normal grooming behavior in mice. |journal=Neuron |volume=33 |issue= 1 |pages= 23–34 |year= 2002 |pmid= 11779477 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

External links

*

PBB_Controls
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