HOXD3

Homeobox D3, also known as HOXD3, is a human gene.cite web | title = Entrez Gene: HOXD3 homeobox D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3232| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.cite web | title = Entrez Gene: HOXD3 homeobox D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3232| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Taniguchi Y, Fujii A, Moriuchi T |title=Cloning and sequencing of the human homeobox gene HOX4A. |journal=Biochim. Biophys. Acta |volume=1132 |issue= 3 |pages= 332–4 |year= 1992 |pmid= 1358204 |doi=
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=Magli MC, Barba P, Celetti A, "et al." |title=Coordinate regulation of HOX genes in human hematopoietic cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 14 |pages= 6348–52 |year= 1991 |pmid= 1712489 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Cannizzaro LA, Croce CM, Griffin CA, "et al." |title=Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13. |journal=Am. J. Hum. Genet. |volume=41 |issue= 1 |pages= 1–15 |year= 1987 |pmid= 2886047 |doi=
*cite journal | author=Taniguchi Y, Komatsu N, Moriuchi T |title=Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. |journal=Blood |volume=85 |issue= 10 |pages= 2786–94 |year= 1995 |pmid= 7742539 |doi=
*cite journal | author=Guazzi S, Lonigro R, Pintonello L, "et al." |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=
*cite journal | author=Manley NR, Capecchi MR |title=Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. |journal=Dev. Biol. |volume=195 |issue= 1 |pages= 1–15 |year= 1998 |pmid= 9520319 |doi= 10.1006/dbio.1997.8827
*cite journal | author=Del Campo M, Jones MC, Veraksa AN, "et al." |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=
*cite journal | author=Myers C, Charboneau A, Boudreau N |title=Homeobox B3 promotes capillary morphogenesis and angiogenesis. |journal=J. Cell Biol. |volume=148 |issue= 2 |pages= 343–51 |year= 2000 |pmid= 10648567 |doi=
*cite journal | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Okubo Y, Hamada J, Takahashi Y, "et al." |title=Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities. |journal=Clin. Exp. Metastasis |volume=19 |issue= 6 |pages= 503–11 |year= 2002 |pmid= 12405287 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Boudreau NJ, Varner JA |title=The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4862–8 |year= 2004 |pmid= 14610084 |doi= 10.1074/jbc.M305190200
*cite journal | author=Hansen SL, Myers CA, Charboneau A, "et al." |title=HoxD3 accelerates wound healing in diabetic mice. |journal=Am. J. Pathol. |volume=163 |issue= 6 |pages= 2421–31 |year= 2004 |pmid= 14633614 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chen Y, Xu B, Arderiu G, "et al." |title=Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. |journal=J. Cereb. Blood Flow Metab. |volume=24 |issue= 11 |pages= 1280–7 |year= 2004 |pmid= 15545924 |doi=

External links

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