FOXP1

FOXP1 ("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors.

PBB_Summary
section_title =
summary_text = This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: FOXP1 forkhead box P1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27086| accessdate = ]

ee also

* FOXP2
* FOXP3
* FOX proteins
*Transcription factors

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Katoh M, Katoh M |title=Human FOX gene family (Review). |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1495–500 |year= 2005 |pmid= 15492844 |doi=
*cite journal | author=Li C, Tucker PW |title=DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 24 |pages= 11583–7 |year= 1994 |pmid= 8265594 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Banham AH, Beasley N, Campo E, "et al." |title=The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. |journal=Cancer Res. |volume=61 |issue= 24 |pages= 8820–9 |year= 2002 |pmid= 11751404 |doi=
*cite journal | author=Wolska MK, Bukowski K, Jakubczak A |title= [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods] |journal=Medycyna doświadczalna i mikrobiologia |volume=53 |issue= 1 |pages= 45–51 |year= 2002 |pmid= 11757404 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang B, Lin D, Li C, Tucker P |title=Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24259–68 |year= 2003 |pmid= 12692134 |doi= 10.1074/jbc.M207174200
*cite journal | author=Li S, Weidenfeld J, Morrisey EE |title=Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 809–22 |year= 2004 |pmid= 14701752 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Teramitsu I, Kudo LC, London SE, "et al." |title=Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. |journal=J. Neurosci. |volume=24 |issue= 13 |pages= 3152–63 |year= 2004 |pmid= 15056695 |doi= 10.1523/JNEUROSCI.5589-03.2004
*cite journal | author=Fox SB, Brown P, Han C, "et al." |title=Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. |journal=Clin. Cancer Res. |volume=10 |issue= 10 |pages= 3521–7 |year= 2004 |pmid= 15161711 |doi= 10.1158/1078-0432.CCR-03-0461
*cite journal | author=Shi C, Zhang X, Chen Z, "et al." |title=Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. |journal=J. Clin. Invest. |volume=114 |issue= 3 |pages= 408–18 |year= 2004 |pmid= 15286807 |doi= 10.1172/JCI200421100
*cite journal | author=Streubel B, Vinatzer U, Lamprecht A, "et al." |title=T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. |journal=Leukemia |volume=19 |issue= 4 |pages= 652–8 |year= 2005 |pmid= 15703784 |doi= 10.1038/sj.leu.2403644
*cite journal | author=Banham AH, Connors JM, Brown PJ, "et al." |title=Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. |journal=Clin. Cancer Res. |volume=11 |issue= 3 |pages= 1065–72 |year= 2005 |pmid= 15709173 |doi=
*cite journal | author=Brown P, Marafioti T, Kusec R, Banham AH |title=The FOXP1 transcription factor is expressed in the majority of follicular lymphomas but is rarely expressed in classical and lymphocyte predominant Hodgkin's lymphoma. |journal=J. Mol. Histol. |volume=36 |issue= 4 |pages= 249–56 |year= 2007 |pmid= 16200457 |doi= 10.1007/s10735-005-6521-3
*cite journal | author=Giatromanolaki A, Koukourakis MI, Sivridis E, "et al." |title=Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression. |journal=Mod. Pathol. |volume=19 |issue= 1 |pages= 9–16 |year= 2006 |pmid= 16258506 |doi= 10.1038/modpathol.3800494
*cite journal | author=Sagaert X, de Paepe P, Libbrecht L, "et al." |title=Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma. |journal=J. Clin. Oncol. |volume=24 |issue= 16 |pages= 2490–7 |year= 2006 |pmid= 16636337 |doi= 10.1200/JCO.2006.05.6150
*cite journal | author=Haralambieva E, Adam P, Ventura R, "et al." |title=Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation. |journal=Leukemia |volume=20 |issue= 7 |pages= 1300–3 |year= 2007 |pmid= 16673020 |doi= 10.1038/sj.leu.2404244
*cite journal | author=Hannenhalli S, Putt ME, Gilmore JM, "et al." |title=Transcriptional genomics associates FOX transcription factors with human heart failure. |journal=Circulation |volume=114 |issue= 12 |pages= 1269–76 |year= 2006 |pmid= 16952980 |doi= 10.1161/CIRCULATIONAHA.106.632430

External links

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