POU3F2

POU domain, class 3, transcription factor 2, also known as POU3F2, is a human gene.cite web | title = Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5454| accessdate = ]

PBB_Summary
section_title =
summary_text = N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression. [supplied by OMIM] cite web | title = Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5454| accessdate = ]

ee also

* Octamer transcription factor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hara Y, Rovescalli AC, Kim Y, Nirenberg M |title=Structure and evolution of four POU domain genes expressed in mouse brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3280–4 |year= 1992 |pmid= 1565620 |doi=
*cite journal | author=Schreiber E, Harshman K, Kemler I, "et al." |title=Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins. |journal=Nucleic Acids Res. |volume=18 |issue= 18 |pages= 5495–503 |year= 1990 |pmid= 2216722 |doi=
*cite journal | author=He X, Treacy MN, Simmons DM, "et al." |title=Expression of a large family of POU-domain regulatory genes in mammalian brain development. |journal=Nature |volume=340 |issue= 6228 |pages= 35–41 |year= 1989 |pmid= 2739723 |doi= 10.1038/340035a0
*cite journal | author=Eisen T, Easty DJ, Bennett DC, Goding CR |title=The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression. |journal=Oncogene |volume=11 |issue= 10 |pages= 2157–64 |year= 1995 |pmid= 7478537 |doi=
*cite journal | author=Atanasoski S, Toldo SS, Malipiero U, "et al." |title=Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. |journal=Genomics |volume=26 |issue= 2 |pages= 272–80 |year= 1995 |pmid= 7601453 |doi=
*cite journal | author=Thomson JA, Murphy K, Baker E, "et al." |title=The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. |journal=Oncogene |volume=11 |issue= 4 |pages= 691–700 |year= 1995 |pmid= 7651733 |doi=
*cite journal | author=Schreiber E, Tobler A, Malipiero U, "et al." |title=cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. |journal=Nucleic Acids Res. |volume=21 |issue= 2 |pages= 253–8 |year= 1993 |pmid= 8441633 |doi=
*cite journal | author=Atanasoski S, Schreiber E, Fontana A, Herr W |title=N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3. |journal=Oncogene |volume=14 |issue= 11 |pages= 1287–94 |year= 1997 |pmid= 9178889 |doi= 10.1038/sj.onc.1200953
*cite journal | author=Petersenn S, Rasch AC, Heyens M, Schulte HM |title=Structure and regulation of the human growth hormone-releasing hormone receptor gene. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 233–47 |year= 1998 |pmid= 9482665 |doi=
*cite journal | author=Kuhlbrodt K, Herbarth B, Sock E, "et al." |title=Cooperative function of POU proteins and SOX proteins in glial cells. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16050–7 |year= 1998 |pmid= 9632656 |doi=
*cite journal | author=Waragai M, Lammers CH, Takeuchi S, "et al." |title=PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival. |journal=Hum. Mol. Genet. |volume=8 |issue= 6 |pages= 977–87 |year= 1999 |pmid= 10332029 |doi=
*cite journal | author=Smit DJ, Smith AG, Parsons PG, "et al." |title=Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. |journal=Eur. J. Biochem. |volume=267 |issue= 21 |pages= 6413–22 |year= 2000 |pmid= 11029584 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jaegle M, Ghazvini M, Mandemakers W, "et al." |title=The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. |journal=Genes Dev. |volume=17 |issue= 11 |pages= 1380–91 |year= 2003 |pmid= 12782656 |doi= 10.1101/gad.258203
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Goodall J, Martinozzi S, Dexter TJ, "et al." |title=Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2915–22 |year= 2004 |pmid= 15024079 |doi=
*cite journal | author=Goodall J, Wellbrock C, Dexter TJ, "et al." |title=The Brn-2 transcription factor links activated BRAF to melanoma proliferation. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2923–31 |year= 2004 |pmid= 15024080 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Cobrinik D, Francis RO, Abramson DH, Lee TC |title=Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells. |journal=Mol. Cancer |volume=5 |issue= |pages= 72 |year= 2007 |pmid= 17163992 |doi= 10.1186/1476-4598-5-72

External links

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