HOXA9

Homeobox A9, also known as HOXA9, is a human gene.

PBB_Summary
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summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.cite web | title = Entrez Gene: HOXA9 homeobox A9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3205| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Nakamura T, Largaespada DA, Lee MP, "et al." |title=Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 154–8 |year= 1996 |pmid= 8563753 |doi= 10.1038/ng0296-154
*cite journal | author=Borrow J, Shearman AM, Stanton VP, "et al." |title=The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 159–67 |year= 1996 |pmid= 8563754 |doi= 10.1038/ng0296-159
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Lawrence HJ, Helgason CD, Sauvageau G, "et al." |title=Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. |journal=Blood |volume=89 |issue= 6 |pages= 1922–30 |year= 1997 |pmid= 9058712 |doi=
*cite journal | author=Kim MH, Chang HH, Shin C, "et al." |title=Genomic structure and sequence analysis of human HOXA-9. |journal=DNA Cell Biol. |volume=17 |issue= 5 |pages= 407–14 |year= 1998 |pmid= 9628584 |doi=
*cite journal | author=Izon DJ, Rozenfeld S, Fong ST, "et al." |title=Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes. |journal=Blood |volume=92 |issue= 2 |pages= 383–93 |year= 1998 |pmid= 9657735 |doi=
*cite journal | author=Patel CV, Sharangpani R, Bandyopadhyay S, DiCorleto PE |title=Endothelial cells express a novel, tumor necrosis factor-alpha-regulated variant of HOXA9. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1415–22 |year= 1999 |pmid= 9880515 |doi=
*cite journal | author=Shen WF, Rozenfeld S, Kwong A, "et al." |title=HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 3051–61 |year= 1999 |pmid= 10082572 |doi=
*cite journal | author=Shi X, Bai S, Li L, Cao X |title=Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 850–5 |year= 2001 |pmid= 11042172 |doi= 10.1074/jbc.M005955200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Schaefer LK, Wang S, Schaefer TS |title=Functional interaction of Jun and homeodomain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43074–82 |year= 2001 |pmid= 11551904 |doi= 10.1074/jbc.M102552200
*cite journal | author=Fujino T, Suzuki A, Ito Y, "et al." |title=Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). |journal=Blood |volume=99 |issue= 4 |pages= 1428–33 |year= 2002 |pmid= 11830496 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Calvo KR, Sykes DB, Pasillas MP, Kamps MP |title=Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. |journal=Oncogene |volume=21 |issue= 27 |pages= 4247–56 |year= 2002 |pmid= 12082612 |doi= 10.1038/sj.onc.1205516
*cite journal | author=Taketani T, Taki T, Ono R, "et al." |title=The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9. |journal=Genes Chromosomes Cancer |volume=34 |issue= 4 |pages= 437–43 |year= 2002 |pmid= 12112533 |doi= 10.1002/gcc.10077
*cite journal | author=Kawakami K, Miyanishi S, Nishii K, "et al." |title=A case of acute myeloid leukemia with t(7;11)(p15;p15) mimicking myeloid crisis of chronic myelogenous leukemia. |journal=Int. J. Hematol. |volume=76 |issue= 1 |pages= 80–3 |year= 2002 |pmid= 12138901 |doi=
*cite journal | author=Mayotte N, Roy DC, Yao J, "et al." |title=Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system. |journal=Blood |volume=100 |issue= 12 |pages= 4177–84 |year= 2003 |pmid= 12393433 |doi= 10.1182/blood-2002-04-1244

External links

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