POU4F1

POU domain, class 4, transcription factor 1, also known as POU4F1, is a human gene.cite web | title = Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5457| accessdate = ]

PBB_Summary
section_title =
summary_text = BRN3A (POU4F1) is a class IV POU domain-containing transcription factor highly expressed in the developing sensory nervous system and in cells of the B- and T-lymphocytic lineages (Gerrero et al., 1993). [supplied by OMIM] cite web | title = Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5457| accessdate = ]

ee also

* BRN-3

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Collum RG, Fisher PE, Datta M, "et al." |title=A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. |journal=Nucleic Acids Res. |volume=20 |issue= 18 |pages= 4919–25 |year= 1992 |pmid= 1357630 |doi=
*cite journal | author=Xiang M, Zhou L, Macke JP, "et al." |title=The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. |journal=J. Neurosci. |volume=15 |issue= 7 Pt 1 |pages= 4762–85 |year= 1995 |pmid= 7623109 |doi=
*cite journal | author=Bhargava AK, Li Z, Weissman SM |title=Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 21 |pages= 10260–4 |year= 1993 |pmid= 8234287 |doi=
*cite journal | author=Gerrero MR, McEvilly RJ, Turner E, "et al." |title=Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10841–5 |year= 1993 |pmid= 8248179 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Still IH, Cowell J |title=The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 3 |pages= 225–6 |year= 1996 |pmid= 8941380 |doi=
*cite journal | author=Smith MD, Dawson SJ, Latchman DS |title=Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1382–8 |year= 1997 |pmid= 8995448 |doi=
*cite journal | author=Budhram-Mahadeo V, Parker M, Latchman DS |title=POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 1029–41 |year= 1998 |pmid= 9448000 |doi=
*cite journal | author=Frass B, Vassen L, Möröy T |title=Gene expression of the POU factor Brn-3a is regulated by two different promoters. |journal=Biochim. Biophys. Acta |volume=1579 |issue= 2-3 |pages= 207–13 |year= 2003 |pmid= 12427558 |doi=
*cite journal | author=Thomas GR, Latchman DS |title=The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription. |journal=Cancer Biol. Ther. |volume=1 |issue= 4 |pages= 428–32 |year= 2003 |pmid= 12432261 |doi=
*cite journal | author=Trieu M, Ma A, Eng SR, "et al." |title=Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a. |journal=Development |volume=130 |issue= 1 |pages= 111–21 |year= 2003 |pmid= 12441296 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ma L, Lei L, Eng SR, "et al." |title=Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. |journal=Development |volume=130 |issue= 15 |pages= 3525–34 |year= 2003 |pmid= 12810599 |doi=
*cite journal | author=Sindos M, Ndisang D, Pisal N, "et al." |title=Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. |journal=Gynecol. Oncol. |volume=90 |issue= 2 |pages= 366–71 |year= 2003 |pmid= 12893201 |doi=
*cite journal | author=Sindos M, Ndisang D, Pisal N, "et al." |title=Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality. |journal=Int. J. Gynecol. Cancer |volume=13 |issue= 4 |pages= 515–7 |year= 2004 |pmid= 12911730 |doi=
*cite journal | author=Calissano M, Latchman DS |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. |journal=Oncogene |volume=22 |issue= 35 |pages= 5408–14 |year= 2003 |pmid= 12934100 |doi= 10.1038/sj.onc.1206635
*cite journal | author=Gascoyne DM, Thomas GR, Latchman DS |title=The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. |journal=Oncogene |volume=23 |issue= 21 |pages= 3830–40 |year= 2004 |pmid= 15021903 |doi= 10.1038/sj.onc.1207497
*cite journal | author=Farooqui-Kabir SR, Budhram-Mahadeo V, Lewis H, "et al." |title=Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a. |journal=Cell Death Differ. |volume=11 |issue= 11 |pages= 1242–4 |year= 2005 |pmid= 15272315 |doi= 10.1038/sj.cdd.4401478
*cite journal | author=Ndisang D, Faulkes DJ, Gascoyne D, "et al." |title=Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. |journal=Oncogene |volume=25 |issue= 1 |pages= 51–60 |year= 2006 |pmid= 16247485 |doi= 10.1038/sj.onc.1209006
*cite journal | author=Diss JK, Faulkes DJ, Walker MM, "et al." |title=Brn-3a neuronal transcription factor functional expression in human prostate cancer. |journal=Prostate Cancer Prostatic Dis. |volume=9 |issue= 1 |pages= 83–91 |year= 2006 |pmid= 16276351 |doi= 10.1038/sj.pcan.4500837

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes