CBFA2T2

Core-binding factor, runt domain, alpha subunit 2; translocated to, 2, also known as CBFA2T2, is a human gene.cite web | title = Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139| accessdate = ]

PBB_Summary
section_title =
summary_text = In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.cite web | title = Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kitabayashi I, Ida K, Morohoshi F, "et al." |title=The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 846–58 |year= 1998 |pmid= 9447981 |doi=
*cite journal | author=Fracchiolla NS, Colombo G, Finelli P, "et al." |title=EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias. |journal=Blood |volume=92 |issue= 9 |pages= 3481–4 |year= 1998 |pmid= 9787195 |doi=
*cite journal | author=Calabi F, Cilli V |title=CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. |journal=Genomics |volume=52 |issue= 3 |pages= 332–41 |year= 1998 |pmid= 9790752 |doi= 10.1006/geno.1998.5429
*cite journal | author=Morohoshi F, Mitani S, Mitsuhashi N, "et al." |title=Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. |journal=Gene |volume=241 |issue= 2 |pages= 287–95 |year= 2000 |pmid= 10675041 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Hoogeveen AT, Rossetti S, Stoyanova V, "et al." |title=The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. |journal=Oncogene |volume=21 |issue= 43 |pages= 6703–12 |year= 2002 |pmid= 12242670 |doi= 10.1038/sj.onc.1205882
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lindberg SR, Olsson A, Persson AM, Olsson I |title=Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. |journal=Eur. J. Haematol. |volume=71 |issue= 6 |pages= 439–47 |year= 2004 |pmid= 14703694 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Zhang J, Kalkum M, Yamamura S, "et al." |title=E protein silencing by the leukemogenic AML1-ETO fusion protein. |journal=Science |volume=305 |issue= 5688 |pages= 1286–9 |year= 2004 |pmid= 15333839 |doi= 10.1126/science.1097937
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Kumar R, Manning J, Spendlove HE, "et al." |title=ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. |journal=Mol. Cancer Res. |volume=4 |issue= 9 |pages= 655–65 |year= 2006 |pmid= 16966434 |doi= 10.1158/1541-7786.MCR-05-0249

External links

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