RGN (gene)

Regucalcin (senescence marker protein-30), also known as RGN, is a human gene.cite web | title = Entrez Gene: RGN regucalcin (senescence marker protein-30)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9104| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.cite web | title = Entrez Gene: RGN regucalcin (senescence marker protein-30)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9104| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fujita T, Shirasawa T, Maruyama N |title=Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. |journal=Mech. Ageing Dev. |volume=107 |issue= 3 |pages= 271–80 |year= 1999 |pmid= 10360682 |doi=
*cite journal | author=Fujita T, Mandel JL, Shirasawa T, "et al." |title=Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. |journal=Biochim. Biophys. Acta |volume=1263 |issue= 3 |pages= 249–52 |year= 1995 |pmid= 7548213 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Misawa H, Yamaguchi M |title=Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. |journal=Int. J. Mol. Med. |volume=5 |issue= 3 |pages= 283–7 |year= 2000 |pmid= 10677570 |doi=
*cite journal | author=Thiselton DL, McDowall J, Brandau O, "et al." |title=An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. |journal=Genomics |volume=79 |issue= 4 |pages= 560–72 |year= 2002 |pmid= 11944989 |doi= 10.1006/geno.2002.6733
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ishigami A, Handa S, Maruyama N, Supakar PC |title=Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase. |journal=Biosci. Biotechnol. Biochem. |volume=67 |issue= 1 |pages= 158–60 |year= 2003 |pmid= 12619687 |doi=
*cite journal | author=Matsuyama S, Kitamura T, Enomoto N, "et al." |title=Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 2 |pages= 386–90 |year= 2004 |pmid= 15358188 |doi= 10.1016/j.bbrc.2004.06.161
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Warizaya M, Kinoshita T, Yamaoka M, "et al." |title=Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=60 |issue= Pt 11 |pages= 2019–21 |year= 2005 |pmid= 15502314 |doi= 10.1107/S0907444904020608
*cite journal | author=Ishigami A, Fujita T, Inoue H, "et al." |title=Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells. |journal=Cell Tissue Res. |volume=320 |issue= 2 |pages= 243–9 |year= 2005 |pmid= 15714273 |doi= 10.1007/s00441-004-1073-5
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Yamaguchi M, Daimon Y |title=Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes. |journal=J. Cell. Biochem. |volume=95 |issue= 6 |pages= 1169–77 |year= 2005 |pmid= 15962315 |doi= 10.1002/jcb.20490

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