NFATC2

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
PDB rendering based on 1a02.
Available structures PDB 1A02, 1OWR, 1P7H, 1PZU, 1S9K, 2AS5, 2O93
Identifiers
Symbols	NFATC2; NFAT1; NFATP
External IDs	OMIM: 600490 MGI: 102463 HomoloGene: 7861 GeneCards: NFATC2 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding Cellular component • nucleus • nucleus • nucleolus • cytoplasm • cytosol • plasma membrane • actin cytoskeleton Biological process • cytokine production • transcription, DNA-dependent • regulation of transcription, DNA-dependent • response to DNA damage stimulus • positive regulation of B cell proliferation • response to drug • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • B cell receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4773	18019
Ensembl	ENSG00000101096	ENSMUSG00000027544
UniProt	Q13469	Q6P3F6
RefSeq (mRNA)	NM_001136021.1	NM_001037177
RefSeq (protein)	NP_001129493.1	NP_001032254
Location (UCSC)	Chr 20: 50 – 50.18 Mb	Chr 2: 168.3 – 168.43 Mb
PubMed search	[1]	[2]

Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.^[1]

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]
NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed NFAT1 (NFATC2) is pro-invasive and pro-migratory in breast carcinoma ^{[3] [4]}

Interactions

NFATC2 has been shown to interact with MEF2D,^[5] EP300,^[6] IRF4^[7] and Protein kinase Mζ.^[8]

See also

• NFAT

References

1. ^ Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jul 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature 369 (6480): 497–502. doi:10.1038/369497a0. PMID 8202141. 
2. ^ "Entrez Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4773. 
3. ^ Jauliac, S; López-Rodriguez, C, Shaw, LM, Brown, LF, Rao, A, Toker, A (2002 Jul). "The role of NFAT transcription factors in integrin-mediated carcinoma invasion.". Nature cell biology 4 (7): 540–4. doi:10.1038/ncb816. PMID 12080349. 
4. ^ Yoeli-Lerner, M; Yiu, GK, Rabinovitz, I, Erhardt, P, Jauliac, S, Toker, A (2005 Nov 23). "Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.". Molecular cell 20 (4): 539–50. PMID 16307918. 
5. ^ Youn, H D; Chatila T A, Liu J O (Aug. 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". EMBO J. (ENGLAND) 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. ISSN 0261-4189. PMC 302027. PMID 10944115. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=302027. 
6. ^ García-Rodríguez, C; Rao A (Jun. 1998). "Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)". J. Exp. Med. (UNITED STATES) 187 (12): 2031–2036. doi:10.1084/jem.187.12.2031. ISSN 0022-1007. PMC 2212364. PMID 9625762. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212364. 
7. ^ Rengarajan, Jyothi; Mowen Kerri A, McBride Kathryn D, Smith Erica D, Singh Harinder, Glimcher Laurie H (Apr. 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. (United States) 195 (8): 1003–1012. doi:10.1084/jem.20011128. ISSN 0022-1007. PMC 2193700. PMID 11956291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193700. 
8. ^ San-Antonio, Belén; Iñiguez Miguel A, Fresno Manuel (Jul. 2002). "Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity". J. Biol. Chem. (United States) 277 (30): 27073–27080. doi:10.1074/jbc.M106983200. ISSN 0021-9258. PMID 12021260. 

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annu. Rev. Immunol. 15: 707–747. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705. 
• Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell 96 (5): 611–614. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. 
• Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–774. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173310. 
• Aramburu J, Azzoni L, Rao A, Perussia B (1995). "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding". J. Exp. Med. 182 (3): 801–810. doi:10.1084/jem.182.3.801. PMC 2192167. PMID 7650486. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2192167. 
• Auffray C, Behar G, Bois F et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816. 
• Li X, Ho SN, Luna J et al. (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenet. Cell Genet. 68 (3–4): 185–191. doi:10.1159/000133910. PMID 7842733. 
• Ho S, Timmerman L, Northrop J, Crabtree GR (1995). "Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT". Adv. Exp. Med. Biol. 365: 167–73. PMID 7887301. 
• Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". Eur. J. Immunol. 24 (11): 2646–2652. doi:10.1002/eji.1830241112. PMID 7957556. 
• Vacca A, Farina M, Maroder M et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochem. Biophys. Res. Commun. 205 (1): 467–474. doi:10.1006/bbrc.1994.2689. PMID 7999066. 
• Jain J, McCaffrey PG, Miner Z et al. (1993). "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun". Nature 365 (6444): 352–355. doi:10.1038/365352a0. PMID 8397339. 
• Luo C, Burgeon E, Carew JA et al. (1996). "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes". Mol. Cell. Biol. 16 (7): 3955–66. PMC 231392. PMID 8668213. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231392. 
• Di Somma MM, Majolini MB, Burastero SE et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". Eur. J. Immunol. 26 (9): 2181–2188. doi:10.1002/eji.1830260933. PMID 8814265. 
• Copeland KF, McKay PJ, Rosenthal KL (1996). "Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element". AIDS Res. Hum. Retroviruses 12 (2): 143–148. doi:10.1089/aid.1996.12.143. PMID 8834464. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Hodge MR, Chun HJ, Rengarajan J et al. (1997). "NF-AT-Driven interleukin-4 transcription potentiated by NIP45". Science 274 (5294): 1903–1905. doi:10.1126/science.274.5294.1903. PMID 8943202. 
• Lyakh L, Ghosh P, Rice NR (1997). "Expression of NFAT-family proteins in normal human T cells". Mol. Cell. Biol. 17 (5): 2475–84. PMC 232096. PMID 9111316. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232096. 
• Amasaki Y, Masuda ES, Imamura R et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". J. Immunol. 160 (5): 2324–33. PMID 9498773. 
• Chen L, Glover JN, Hogan PG et al. (1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA". Nature 392 (6671): 42–48. doi:10.1038/32100. PMID 9510247. 

External links

• MeSH NFATC2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.