SIM2

Single-minded homolog 2 (Drosophila), also known as SIM2, is a human gene.cite web | title = Entrez Gene: SIM2 single-minded homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6493| accessdate = ]

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summary_text = SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypescite web | title = Entrez Gene: SIM2 single-minded homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6493| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Muenke M, Bone LJ, Mitchell HF, "et al." |title=Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. |journal=Am. J. Hum. Genet. |volume=57 |issue= 5 |pages= 1074–9 |year= 1995 |pmid= 7485157 |doi=
*cite journal | author=Dahmane N, Charron G, Lopes C, "et al." |title=Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 20 |pages= 9191–5 |year= 1995 |pmid= 7568099 |doi=
*cite journal | author=Chen H, Chrast R, Rossier C, "et al." |title=Single-minded and Down syndrome? |journal=Nat. Genet. |volume=10 |issue= 1 |pages= 9–10 |year= 1995 |pmid= 7647800 |doi= 10.1038/ng0595-9
*cite journal | author=Yamaki A, Noda S, Kudoh J, "et al." |title=The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. |journal=Genomics |volume=35 |issue= 1 |pages= 136–43 |year= 1996 |pmid= 8661114 |doi= 10.1006/geno.1996.0332
*cite journal | author=Fan CM, Kuwana E, Bulfone A, "et al." |title=Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. |journal=Mol. Cell. Neurosci. |volume=7 |issue= 1 |pages= 1–16 |year= 1996 |pmid= 8812055 |doi= 10.1006/mcne.1996.0001
*cite journal | author=Osoegawa K, Okano S, Kato Y, "et al." |title=A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region. |journal=DNA Res. |volume=3 |issue= 3 |pages= 175–9 |year= 1997 |pmid= 8905236 |doi=
*cite journal | author=Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O |title=Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4451–7 |year= 1997 |pmid= 9020169 |doi=
*cite journal | author=Chrast R, Scott HS, Chen H, "et al." |title=Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. |journal=Genome Res. |volume=7 |issue= 6 |pages= 615–24 |year= 1997 |pmid= 9199934 |doi=
*cite journal | author=Moffett P, Reece M, Pelletier J |title=The murine Sim-2 gene product inhibits transcription by active repression and functional interference. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 4933–47 |year= 1997 |pmid= 9271372 |doi=
*cite journal | author=Dahmane N, Ghezala GA, Gosset P, "et al." |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. |journal=Genomics |volume=48 |issue= 1 |pages= 12–23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146
*cite journal | author=Ema M, Ikegami S, Hosoya T, "et al." |title=Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome. |journal=Hum. Mol. Genet. |volume=8 |issue= 8 |pages= 1409–15 |year= 1999 |pmid= 10400987 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Yamaki A, Tochigi J, Kudoh J, "et al." |title=Molecular mechanisms of human single-minded 2 (SIM2) gene expression: identification of a promoter site in the SIM2 genomic sequence. |journal=Gene |volume=270 |issue= 1-2 |pages= 265–75 |year= 2001 |pmid= 11404025 |doi=
*cite journal | author=Woods SL, Whitelaw ML |title=Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10236–43 |year= 2002 |pmid= 11782478 |doi= 10.1074/jbc.M110752200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deyoung MP, Scheurle D, Damania H, "et al." |title=Down's syndrome-associated single minded gene as a novel tumor marker. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3149–57 |year= 2003 |pmid= 12530058 |doi=
*cite journal | author=DeYoung MP, Tress M, Narayanan R |title=Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4760–5 |year= 2003 |pmid= 12676991 |doi= 10.1073/pnas.0831000100
*cite journal | author=DeYoung MP, Tress M, Narayanan R |title=Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target. |journal=Cancer Lett. |volume=200 |issue= 1 |pages= 25–31 |year= 2003 |pmid= 14550949 |doi=
*cite journal | author=Yamaki A, Kudoh J, Shimizu N, Shimizu Y |title=A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 482–8 |year= 2004 |pmid= 14697214 |doi=
*cite journal | author=Ooe N, Saito K, Mikami N, "et al." |title=Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 608–16 |year= 2004 |pmid= 14701734 |doi=

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