ARNT2

Aryl-hydrocarbon receptor nuclear translocator 2, also known as ARNT2, is a human gene.cite web | title = Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9915| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.cite web | title = Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9915| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Moffett P, Pelletier J |title=Different transcriptional properties of mSim-1 and mSim-2. |journal=FEBS Lett. |volume=466 |issue= 1 |pages= 80–6 |year= 2000 |pmid= 10648817 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Wines ME, Lee L, Katari MS, "et al." |title=Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. |journal=Genomics |volume=72 |issue= 1 |pages= 88–98 |year= 2001 |pmid= 11247670 |doi= 10.1006/geno.2000.6466
*cite journal | author=Barrow LL, Wines ME, Romitti PA, "et al." |title=Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts. |journal=Teratology |volume=66 |issue= 2 |pages= 85–90 |year= 2003 |pmid= 12210012 |doi= 10.1002/tera.10062
*cite journal | author=Stolze I, Berchner-Pfannschmidt U, Freitag P, "et al." |title=Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. |journal=Blood |volume=100 |issue= 7 |pages= 2623–8 |year= 2002 |pmid= 12239177 |doi= 10.1182/blood-2001-12-0169
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ooe N, Saito K, Mikami N, "et al." |title=Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 608–16 |year= 2004 |pmid= 14701734 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Friedman ER, Fan CM |title=Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription. |journal=Biochem. Biophys. Res. Commun. |volume=363 |issue= 1 |pages= 113–8 |year= 2007 |pmid= 17826745 |doi= 10.1016/j.bbrc.2007.08.108

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