N-Myc

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Identifiers
Symbols	MYCN; MODED; N-myc; NMYC; ODED; bHLHe37
External IDs	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding Cellular component • chromatin • nucleus Biological process • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4613	18109
Ensembl	ENSG00000134323	ENSMUSG00000037169
UniProt	P04198	Q3UII1
RefSeq (mRNA)	NM_005378.4	NM_008709.3
RefSeq (protein)	NP_005369.2	NP_032735.3
Location (UCSC)	Chr 2: 16.08 – 16.09 Mb	Chr 12: 12.94 – 12.95 Mb
PubMed search	[1]	[2]

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), also known as MYCN, is a protein which in humans is encoded by the MYCN gene.

Function

This gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.^[1]

Clinical significance

Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.^[2]

Interactions

N-Myc has been shown to interact with MAX.^[3][4]

N-Myc is also stabilized by Aurora A which protects it from degradation.^[5]

See also

• Myc

References

1. ^ "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4613. 
2. ^ Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet. 4 (2): 191–4. doi:10.1038/ng0693-191. PMID 8102299. 
3. ^ Blackwood, E M; Eisenman R N (Mar. 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science (UNITED STATES) 251 (4998): 1211–7. doi:10.1126/science.2006410. ISSN 0036-8075. PMID 2006410. 
4. ^ FitzGerald, M J; Arsura M, Bellas R E, Yang W, Wu M, Chin L, Mann K K, DePinho R A, Sonenshein G E (Apr. 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene (ENGLAND) 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. ISSN 0950-9232. PMID 10229200. 
5. ^ Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma Cancer Cell, Volume 15, Issue 1, 6 January 2009, Pages 67-78, Tobias Otto, Sebastian Horn, Markus Brockmann, Ursula Eilers, Lars Schüttrumpf, Nikita Popov, Anna Marie Kenney, Johannes H. Schulte, Roderick Beijersbergen, Holger Christiansen, Bernd Berwanger, Martin Eilers

Further reading

• Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network.". Gene 277 (1-2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341. 
• Armstrong BC, Krystal GW (1992). "Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.". Cell Growth Differ. 3 (6): 385–90. PMID 1419902. 
• Hagiwara T, Nakaya K, Nakamura Y, et al. (1992). "Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.". Eur. J. Biochem. 209 (3): 945–50. doi:10.1111/j.1432-1033.1992.tb17367.x. PMID 1425701. 
• Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1).". Nucleic Acids Res. 20 (5): 1165. doi:10.1093/nar/20.5.1165. PMC 312136. PMID 1549498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312136. 
• Krystal GW, Armstrong BC, Battey JF (1990). "N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.". Mol. Cell. Biol. 10 (8): 4180–91. PMC 360949. PMID 1695323. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360949. 
• Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc.". Science 251 (4998): 1211–7. doi:10.1126/science.2006410. PMID 2006410. 
• Emanuel BS, Balaban G, Boyd JP, et al. (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=397862. 
• Ibson JM, Rabbitts PH (1988). "Sequence of a germ-line N-myc gene and amplification as a mechanism of activation.". Oncogene 2 (4): 399–402. PMID 2834684. 
• Stanton LW, Schwab M, Bishop JM (1986). "Nucleotide sequence of the human N-myc gene.". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1772–6. doi:10.1073/pnas.83.6.1772. PMC 323166. PMID 2869488. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=323166. 
• Michitsch RW, Melera PW (1985). "Nucleotide sequence of the 3' exon of the human N-myc gene.". Nucleic Acids Res. 13 (7): 2545–58. doi:10.1093/nar/13.7.2545. PMC 341174. PMID 2987858. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=341174. 
• Slamon DJ, Boone TC, Seeger RC, et al. (1986). "Identification and characterization of the protein encoded by the human N-myc oncogene.". Science 232 (4751): 768–72. doi:10.1126/science.3008339. PMID 3008339. 
• Garson JA, van den Berghe JA, Kemshead JT (1987). "Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and beta-NGF genes.". Nucleic Acids Res. 15 (12): 4761–70. doi:10.1093/nar/15.12.4761. PMC 305916. PMID 3299258. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305916. 
• Stanton LW, Bishop JM (1988). "Alternative processing of RNA transcribed from NMYC.". Mol. Cell. Biol. 7 (12): 4266–72. PMC 368108. PMID 3437890. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=368108. 
• Kohl NE, Legouy E, DePinho RA, et al. (1986). "Human N-myc is closely related in organization and nucleotide sequence to c-myc.". Nature 319 (6048): 73–7. doi:10.1038/319073a0. PMID 3510398. 
• Grady EF, Schwab M, Rosenau W (1987). "Expression of N-myc and c-src during the development of fetal human brain.". Cancer Res. 47 (11): 2931–6. PMID 3552210. 
• Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA.". Mol. Cell. Biol. 6 (12): 4450–7. PMC 367228. PMID 3796607. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367228. 
• Brodeur GM, Seeger RC (1986). "Gene amplification in human neuroblastomas: basic mechanisms and clinical implications.". Cancer Genet. Cytogenet. 19 (1-2): 101–11. doi:10.1016/0165-4608(86)90377-8. PMID 3940169. 
• Kanda N, Schreck R, Alt F, et al. (1983). "Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 80 (13): 4069–73. doi:10.1073/pnas.80.13.4069. PMC 394202. PMID 6575396. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394202. 
• Schwab M, Varmus HE, Bishop JM, et al. (1984). "Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.". Nature 308 (5956): 288–91. doi:10.1038/308288a0. PMID 6700732. 
• Brodeur GM, Seeger RC, Schwab M, et al. (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.". Science 224 (4653): 1121–4. doi:10.1126/science.6719137. PMID 6719137. 

External links

• MeSH MYCN+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.