BACH1

BTB and CNC homology 1, basic leucine zipper transcription factor 1, also known as BACH1, is a human gene.cite web | title = Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=571| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.cite web | title = Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=571| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ozono R |title=New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. |journal=Current pharmaceutical biotechnology |volume=7 |issue= 2 |pages= 87–93 |year= 2006 |pmid= 16724942 |doi=
*cite journal | author=Oyake T, Itoh K, Motohashi H, "et al." |title=Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6083–95 |year= 1996 |pmid= 8887638 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ohira M, Seki N, Nagase T, "et al." |title=Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. |journal=Genomics |volume=47 |issue= 2 |pages= 300–6 |year= 1998 |pmid= 9479503 |doi=
*cite journal | author=Blouin JL, Duriaux Saïl G, Guipponi M, "et al." |title=Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. |journal=Hum. Genet. |volume=102 |issue= 3 |pages= 282–8 |year= 1998 |pmid= 9544839 |doi=
*cite journal | author=Kobayashi A, Yamagiwa H, Hoshino H, "et al." |title=A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1733–46 |year= 2000 |pmid= 10669750 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Kanezaki R, Toki T, Yokoyama M, "et al." |title=Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 7278–84 |year= 2001 |pmid= 11069897 |doi= 10.1074/jbc.M004227200
*cite journal | author=Cantor SB, Bell DW, Ganesan S, "et al." |title=BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. |journal=Cell |volume=105 |issue= 1 |pages= 149–60 |year= 2001 |pmid= 11301010 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kitamuro T, Takahashi K, Ogawa K, "et al." |title=Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9125–33 |year= 2003 |pmid= 12511571 |doi= 10.1074/jbc.M209939200
*cite journal | author=Suzuki H, Tashiro S, Sun J, "et al." |title=Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49246–53 |year= 2004 |pmid= 14504288 |doi= 10.1074/jbc.M306764200
*cite journal | author=Tahara T, Sun J, Nakanishi K, "et al." |title=Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5480–7 |year= 2004 |pmid= 14660636 |doi= 10.1074/jbc.M302733200
*cite journal | author=Shim KS, Ferrando-Miguel R, Lubec G |title=Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 39–49 |year= 2004 |pmid= 15068237 |doi=
*cite journal | author=Ferrando-Miguel R, Cheon MS, Yang JW, Lubec G |title=Overexpression of transcription factor BACH1 in fetal Down syndrome brain. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 193–205 |year= 2004 |pmid= 15068251 |doi=
*cite journal | author=Suzuki H, Tashiro S, Hira S, "et al." |title=Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. |journal=EMBO J. |volume=23 |issue= 13 |pages= 2544–53 |year= 2005 |pmid= 15175654 |doi= 10.1038/sj.emboj.7600248
*cite journal | author=Tahara T, Sun J, Igarashi K, Taketani S |title=Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 77–85 |year= 2004 |pmid= 15464985 |doi= 10.1016/j.bbrc.2004.09.022
*cite journal | author=Shan Y, Lambrecht RW, Ghaziani T, "et al." |title=Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 51769–74 |year= 2005 |pmid= 15465821 |doi= 10.1074/jbc.M409463200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Toki T, Katsuoka F, Kanezaki R, "et al." |title=Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. |journal=Blood |volume=105 |issue= 8 |pages= 3100–8 |year= 2005 |pmid= 15613547 |doi= 10.1182/blood-2004-07-2826

External links

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