- HMOX1
HMOX1 (heme oxygenase (decycling) 1) is a
human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase is an essential enzyme inheme catabolism , it cleavesheme to formbiliverdin .PBB_Summary
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summary_text = Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [cite web | title = Entrez Gene: HMOX1 heme oxygenase (decycling) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3162| accessdate = ]The HMOX gene is located on the long (q) arm of chromosome 22 at position 13.1, from base pair 34,101,636 to base pair 34,114,748.
Related conditions
Heme oxygenase-1 deficiency ee also
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HMOX2 References
Further reading
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citations =
*cite journal | author=Soares MP, Brouard S, Smith RN, Bach FH |title=Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. |journal=Immunol. Rev. |volume=184 |issue= |pages= 275–85 |year= 2002 |pmid= 12086318 |doi=
*cite journal | author=Morse D, Choi AM |title=Heme oxygenase-1: the "emerging molecule" has arrived. |journal=Am. J. Respir. Cell Mol. Biol. |volume=27 |issue= 1 |pages= 8–16 |year= 2002 |pmid= 12091240 |doi=
*cite journal | author=Buelow R, Tullius SG, Volk HD |title=Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. |journal=Am. J. Transplant. |volume=1 |issue= 4 |pages= 313–5 |year= 2002 |pmid= 12099373 |doi=
*cite journal | author=Ishikawa K |title=Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. |journal=Curr. Pharm. Des. |volume=9 |issue= 30 |pages= 2489–97 |year= 2003 |pmid= 14529548 |doi=
*cite journal | author=Exner M, Minar E, Wagner O, Schillinger M |title=The role of heme oxygenase-1 promoter polymorphisms in human disease. |journal=Free Radic. Biol. Med. |volume=37 |issue= 8 |pages= 1097–104 |year= 2005 |pmid= 15451051 |doi= 10.1016/j.freeradbiomed.2004.07.008
*cite journal | author=Ozono R |title=New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. |journal=Current pharmaceutical biotechnology |volume=7 |issue= 2 |pages= 87–93 |year= 2006 |pmid= 16724942 |doi=
*cite journal | author=Tracz MJ, Alam J, Nath KA |title=Physiology and pathophysiology of heme: implications for kidney disease. |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 2 |pages= 414–20 |year= 2007 |pmid= 17229906 |doi= 10.1681/ASN.2006080894
*cite journal | author=Hill-Kapturczak N, Agarwal A |title=Haem oxygenase-1--a culprit in vascular and renal damage? |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 6 |pages= 1495–9 |year= 2007 |pmid= 17389623 |doi= 10.1093/ndt/gfm093PBB_Controls
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