HMOX2

Heme oxygenase (decycling) 2, also known as HMOX2, is a human gene.

PBB_Summary
section_title =
summary_text = Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.cite web | title = Entrez Gene: HMOX2 heme oxygenase (decycling) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3163| accessdate = ]

References

Further reading

*cite journal | author=Bianchetti CM, Yi L, Ragsdale SW, Phillips GN Jr. |title=Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2. |journal=J Biol Chem. |volume=282 |issue= 52 |pages= 37624–31 |year= 2007 |pmid= 17965015 |doi=10.1074/jbc.M707396200 PBB_Further_reading
citations =
*cite journal | author=Barañano DE, Snyder SH |title=Neural roles for heme oxygenase: contrasts to nitric oxide synthase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 20 |pages= 10996–1002 |year= 2001 |pmid= 11572959 |doi= 10.1073/pnas.191351298
*cite journal | author=Doré S |title=Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease. |journal=Free Radic. Biol. Med. |volume=32 |issue= 12 |pages= 1276–82 |year= 2002 |pmid= 12057765 |doi=10.1016/S0891-5849(02)00805-5
*cite journal | author=Kemp PJ |title=Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 1 |pages= 648–52 |year= 2005 |pmid= 16137652 |doi= 10.1016/j.bbrc.2005.08.110
*cite journal | author=McCoubrey WK, Ewing JF, Maines MD |title=Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. |journal=Arch. Biochem. Biophys. |volume=295 |issue= 1 |pages= 13–20 |year= 1992 |pmid= 1575508 |doi=10.1016/0003-9861(92)90481-B
*cite journal | author=Ishikawa K, Takeuchi N, Takahashi S, "et al." |title=Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6345–50 |year= 1995 |pmid= 7890772 |doi=10.1074/jbc.270.11.6345
*cite journal | author=Kutty RK, Kutty G, Rodriguez IR, "et al." |title=Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3. |journal=Genomics |volume=20 |issue= 3 |pages= 513–6 |year= 1994 |pmid= 8034330 |doi= 10.1006/geno.1994.1213
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Takahashi K, Hara E, Suzuki H, "et al." |title=Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors. |journal=J. Neurochem. |volume=67 |issue= 2 |pages= 482–9 |year= 1996 |pmid= 8764571 |doi=
*cite journal | author=Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S |title=Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 180–1 |year= 1997 |pmid= 9284910 |doi=10.1159/000134570
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Yoshiki N, Kubota T, Aso T |title=Expression and localization of heme oxygenase in human placental villi. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 1136–42 |year= 2000 |pmid= 11027601 |doi= 10.1006/bbrc.2000.3551
*cite journal | author=Hanselmann C, Mauch C, Werner S |title=Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis? |journal=Biochem. J. |volume=353 |issue= Pt 3 |pages= 459–66 |year= 2001 |pmid= 11171041 |doi=10.1042/0264-6021:3530459
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Appleton SD, Marks GS, Nakatsu K, "et al." |title=Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=284 |issue= 3 |pages= H853–8 |year= 2003 |pmid= 12578814 |doi= 10.1152/ajpheart.00655.2002 | doi_brokendate=2008-10-03
*cite journal | author=Galey D, Becker K, Haughey N, "et al." |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=10.1080/713831545
*cite journal | author=Zenclussen AC, Lim E, Knoeller S, "et al." |title=Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies. |journal=Am. J. Reprod. Immunol. |volume=50 |issue= 1 |pages= 66–76 |year= 2004 |pmid= 14506930 |doi=10.1034/j.1600-0897.2003.00047.x
*cite journal | author=Boehning D, Moon C, Sharma S, "et al." |title=Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. |journal=Neuron |volume=40 |issue= 1 |pages= 129–37 |year= 2003 |pmid= 14527438 |doi=10.1016/S0896-6273(03)00596-8
*cite journal | author=Appleton SD, Lash GE, Marks GS, "et al." |title=Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=285 |issue= 6 |pages= R1453–60 |year= 2004 |pmid= 14615405 |doi= 10.1152/ajpregu.00234.2003 | doi_brokendate=2008-10-03

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