HLF (gene)

Hepatic leukemia factor, also known as HLF, is a human gene.cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=LeBrun DP |title=E2A basic helix-loop-helix transcription factors in human leukemia. |journal=Front. Biosci. |volume=8 |issue= |pages= s206–22 |year= 2004 |pmid= 12700034 |doi=
*cite journal | author=Inaba T, Roberts WM, Shapiro LH, "et al." |title=Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. |journal=Science |volume=257 |issue= 5069 |pages= 531–4 |year= 1992 |pmid= 1386162 |doi=
*cite journal | author=Hunger SP, Ohyashiki K, Toyama K, Cleary ML |title=Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. |journal=Genes Dev. |volume=6 |issue= 9 |pages= 1608–20 |year= 1992 |pmid= 1516826 |doi=
*cite journal | author=Falvey E, Fleury-Olela F, Schibler U |title=The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4307–17 |year= 1995 |pmid= 7556072 |doi=
*cite journal | author=Hunger SP, Brown R, Cleary ML |title=DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. |journal=Mol. Cell. Biol. |volume=14 |issue= 9 |pages= 5986–96 |year= 1994 |pmid= 8065331 |doi=
*cite journal | author=Inaba T, Shapiro LH, Funabiki T, "et al." |title=DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. |journal=Mol. Cell. Biol. |volume=14 |issue= 5 |pages= 3403–13 |year= 1994 |pmid= 8164688 |doi=
*cite journal | author=Hunger SP |title=Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. |journal=Blood |volume=87 |issue= 4 |pages= 1211–24 |year= 1996 |pmid= 8608207 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Hunger SP, Li S, Fall MZ, "et al." |title=The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. |journal=Blood |volume=87 |issue= 11 |pages= 4607–17 |year= 1996 |pmid= 8639829 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Takahata S, Sogawa K, Kobayashi A, "et al." |title=Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 789–94 |year= 1998 |pmid= 9704006 |doi= 10.1006/bbrc.1998.9012
*cite journal | author=Inukai T, Inaba T, Ikushima S, Look AT |title=The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 6035–43 |year= 1998 |pmid= 9742120 |doi=
*cite journal | author=Begbie M, Mueller C, Lillicrap D |title=Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes. |journal=DNA Cell Biol. |volume=18 |issue= 2 |pages= 165–73 |year= 1999 |pmid= 10073576 |doi= 10.1089/104454999315556
*cite journal | author=Ema M, Hirota K, Mimura J, "et al." |title=Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1905–14 |year= 1999 |pmid= 10202154 |doi= 10.1093/emboj/18.7.1905
*cite journal | author=Honda H, Inaba T, Suzuki T, "et al." |title=Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. |journal=Blood |volume=93 |issue= 9 |pages= 2780–90 |year= 1999 |pmid= 10216071 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsunaga T, Inaba T, Matsui H, "et al." |title=Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. |journal=Blood |volume=103 |issue= 8 |pages= 3185–91 |year= 2004 |pmid= 15070701 |doi= 10.1182/blood-2003-09-3022
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

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