HEY1

Hairy/enhancer-of-split related with YRPW motif 1, also known as HEY1, is a human gene.cite web | title = Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23462| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.cite web | title = Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23462| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Iso T, Kedes L, Hamamori Y |title=HES and HERP families: multiple effectors of the Notch signaling pathway. |journal=J. Cell. Physiol. |volume=194 |issue= 3 |pages= 237–55 |year= 2003 |pmid= 12548545 |doi= 10.1002/jcp.10208
*cite journal | author=Kokubo H, Miyagawa-Tomita S, Johnson RL |title=Hesr, a mediator of the Notch signaling, functions in heart and vessel development. |journal=Trends Cardiovasc. Med. |volume=15 |issue= 5 |pages= 190–4 |year= 2006 |pmid= 16165016 |doi= 10.1016/j.tcm.2005.05.005
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kokubo H, Lun Y, Johnson RL |title=Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 2 |pages= 459–65 |year= 1999 |pmid= 10403790 |doi= 10.1006/bbrc.1999.0880
*cite journal | author=Leimeister C, Externbrink A, Klamt B, Gessler M |title=Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. |journal=Mech. Dev. |volume=85 |issue= 1-2 |pages= 173–7 |year= 1999 |pmid= 10415358 |doi=
*cite journal | author=Chin MT, Maemura K, Fukumoto S, "et al." |title=Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6381–7 |year= 2000 |pmid= 10692439 |doi=
*cite journal | author=Steidl C, Leimeister C, Klamt B, "et al." |title=Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. |journal=Genomics |volume=66 |issue= 2 |pages= 195–203 |year= 2000 |pmid= 10860664 |doi= 10.1006/geno.2000.6200
*cite journal | author=Maier MM, Gessler M |title=Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 2 |pages= 652–60 |year= 2000 |pmid= 10964718 |doi= 10.1006/bbrc.2000.3354
*cite journal | author=Nakagawa O, McFadden DG, Nakagawa M, "et al." |title=Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13655–60 |year= 2001 |pmid= 11095750 |doi= 10.1073/pnas.250485597
*cite journal | author=Sun J, Kamei CN, Layne MD, "et al." |title=Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18591–6 |year= 2001 |pmid= 11279181 |doi= 10.1074/jbc.M101163200
*cite journal | author=Iso T, Sartorelli V, Chung G, "et al." |title=HERP, a new primary target of Notch regulated by ligand binding. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6071–9 |year= 2001 |pmid= 11486044 |doi=
*cite journal | author=Taylor KL, Henderson AM, Hughes CC |title=Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. |journal=Microvasc. Res. |volume=64 |issue= 3 |pages= 372–83 |year= 2003 |pmid= 12453432 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Elagib KE, Xiao M, Hussaini IM, "et al." |title=Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7779–94 |year= 2004 |pmid= 15314183 |doi= 10.1128/MCB.24.17.7779-7794.2004
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kokubo H, Miyagawa-Tomita S, Nakazawa M, "et al." |title=Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. |journal=Dev. Biol. |volume=278 |issue= 2 |pages= 301–9 |year= 2005 |pmid= 15680351 |doi= 10.1016/j.ydbio.2004.10.025

External links

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PBB_Controls
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