FBXO5

F-box protein 5, also known as FBXO5, is a human gene.cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gubin AN, Njoroge JM, Bouffard GG, Miller JL |title=Gene expression in proliferating human erythroid cells. |journal=Genomics |volume=59 |issue= 2 |pages= 168–77 |year= 1999 |pmid= 10409428 |doi= 10.1006/geno.1999.5855
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Chiaur DS, Murthy S, Cenciarelli C, "et al." |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255–8 |year= 2000 |pmid= 10828603 |doi=
*cite journal | author=Reimann JD, Freed E, Hsu JY, "et al." |title=Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. |journal=Cell |volume=105 |issue= 5 |pages= 645–55 |year= 2001 |pmid= 11389834 |doi=
*cite journal | author=Reimann JD, Jackson PK |title=Emi1 is required for cytostatic factor arrest in vertebrate eggs. |journal=Nature |volume=416 |issue= 6883 |pages= 850–4 |year= 2002 |pmid= 11976684 |doi= 10.1038/416850a
*cite journal | author=Hsu JY, Reimann JD, Sørensen CS, "et al." |title=E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). |journal=Nat. Cell Biol. |volume=4 |issue= 5 |pages= 358–66 |year= 2002 |pmid= 11988738 |doi= 10.1038/ncb785
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li Z, Hu CY, Mo BQ, "et al." |title= [Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380–4 |year= 2003 |pmid= 12703993 |doi=
*cite journal | author=Margottin-Goguet F, Hsu JY, Loktev A, "et al." |title=Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. |journal=Dev. Cell |volume=4 |issue= 6 |pages= 813–26 |year= 2003 |pmid= 12791267 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Moshe Y, Boulaire J, Pagano M, Hershko A |title=Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 21 |pages= 7937–42 |year= 2004 |pmid= 15148369 |doi= 10.1073/pnas.0402442101
*cite journal | author=Hansen DV, Loktev AV, Ban KH, Jackson PK |title=Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5623–34 |year= 2005 |pmid= 15469984 |doi= 10.1091/mbc.E04-07-0598
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Eldridge AG, Loktev AV, Hansen DV, "et al." |title=The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. |journal=Cell |volume=124 |issue= 2 |pages= 367–80 |year= 2006 |pmid= 16439210 |doi= 10.1016/j.cell.2005.10.038
*cite journal | author=Lehman NL, Verschuren EW, Hsu JY, "et al." |title=Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1569–73 |year= 2006 |pmid= 16861914 |doi=
*cite journal | author=Miller JJ, Summers MK, Hansen DV, "et al." |title=Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. |journal=Genes Dev. |volume=20 |issue= 17 |pages= 2410–20 |year= 2006 |pmid= 16921029 |doi= 10.1101/gad.1454006
*cite journal | author=Marangos P, Verschuren EW, Chen R, "et al." |title=Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). |journal=J. Cell Biol. |volume=176 |issue= 1 |pages= 65–75 |year= 2007 |pmid= 17190794 |doi= 10.1083/jcb.200607070

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