FBXO5

FBXO5

F-box protein 5, also known as FBXO5, is a human gene.cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gubin AN, Njoroge JM, Bouffard GG, Miller JL |title=Gene expression in proliferating human erythroid cells. |journal=Genomics |volume=59 |issue= 2 |pages= 168–77 |year= 1999 |pmid= 10409428 |doi= 10.1006/geno.1999.5855
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Chiaur DS, Murthy S, Cenciarelli C, "et al." |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255–8 |year= 2000 |pmid= 10828603 |doi=
*cite journal | author=Reimann JD, Freed E, Hsu JY, "et al." |title=Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. |journal=Cell |volume=105 |issue= 5 |pages= 645–55 |year= 2001 |pmid= 11389834 |doi=
*cite journal | author=Reimann JD, Jackson PK |title=Emi1 is required for cytostatic factor arrest in vertebrate eggs. |journal=Nature |volume=416 |issue= 6883 |pages= 850–4 |year= 2002 |pmid= 11976684 |doi= 10.1038/416850a
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*cite journal | author=Hansen DV, Loktev AV, Ban KH, Jackson PK |title=Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5623–34 |year= 2005 |pmid= 15469984 |doi= 10.1091/mbc.E04-07-0598
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*cite journal | author=Eldridge AG, Loktev AV, Hansen DV, "et al." |title=The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. |journal=Cell |volume=124 |issue= 2 |pages= 367–80 |year= 2006 |pmid= 16439210 |doi= 10.1016/j.cell.2005.10.038
*cite journal | author=Lehman NL, Verschuren EW, Hsu JY, "et al." |title=Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1569–73 |year= 2006 |pmid= 16861914 |doi=
*cite journal | author=Miller JJ, Summers MK, Hansen DV, "et al." |title=Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. |journal=Genes Dev. |volume=20 |issue= 17 |pages= 2410–20 |year= 2006 |pmid= 16921029 |doi= 10.1101/gad.1454006
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