SREBF2

Sterol regulatory element binding transcription factor 2, also known as SREBF2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.cite web | title = Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6721| accessdate = ]

ee also

* Sterol regulatory element binding protein

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Osborne TF |title=CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin. |journal=Genes Dev. |volume=15 |issue= 15 |pages= 1873–8 |year= 2001 |pmid= 11485982 |doi= 10.1101/gad.916601
*cite journal | author=Szolkiewicz M, Chmielewski M, Nogalska A, "et al." |title=The potential role of sterol regulatory element binding protein transcription factors in renal injury. |journal=Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation |volume=17 |issue= 1 |pages= 62–5 |year= 2007 |pmid= 17198935 |doi= 10.1053/j.jrn.2006.10.009
*cite journal | author=Hua X, Wu J, Goldstein JL, "et al." |title=Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. |journal=Genomics |volume=25 |issue= 3 |pages= 667–73 |year= 1995 |pmid= 7759101 |doi=
*cite journal | author=Hua X, Yokoyama C, Wu J, "et al." |title=SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 24 |pages= 11603–7 |year= 1994 |pmid= 7903453 |doi=
*cite journal | author=Yokoyama C, Wang X, Briggs MR, "et al." |title=SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. |journal=Cell |volume=75 |issue= 1 |pages= 187–97 |year= 1993 |pmid= 8402897 |doi=
*cite journal | author=Wang X, Zelenski NG, Yang J, "et al." |title=Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1012–20 |year= 1996 |pmid= 8605870 |doi=
*cite journal | author=Hua X, Sakai J, Brown MS, Goldstein JL |title=Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10379–84 |year= 1996 |pmid= 8626610 |doi=
*cite journal | author=Pai JT, Brown MS, Goldstein JL |title=Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 11 |pages= 5437–42 |year= 1996 |pmid= 8643593 |doi=
*cite journal | author=Sato R, Inoue J, Kawabe Y, "et al." |title=Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26461–4 |year= 1996 |pmid= 8900111 |doi=
*cite journal | author=Oliner JD, Andresen JM, Hansen SK, "et al." |title=SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. |journal=Genes Dev. |volume=10 |issue= 22 |pages= 2903–11 |year= 1996 |pmid= 8918891 |doi=
*cite journal | author=Miserez AR, Cao G, Probst LC, Hobbs HH |title=Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). |journal=Genomics |volume=40 |issue= 1 |pages= 31–40 |year= 1997 |pmid= 9070916 |doi= 10.1006/geno.1996.4525
*cite journal | author=Duncan EA, Brown MS, Goldstein JL, Sakai J |title=Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2. |journal=J. Biol. Chem. |volume=272 |issue= 19 |pages= 12778–85 |year= 1997 |pmid= 9139737 |doi=
*cite journal | author=Harris IR, Farrell AM, Holleran WM, "et al." |title=Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis. |journal=J. Lipid Res. |volume=39 |issue= 2 |pages= 412–22 |year= 1998 |pmid= 9508001 |doi=
*cite journal | author=Kan HY, Pissios P, Chambaz J, Zannis VI |title=DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter. |journal=Nucleic Acids Res. |volume=27 |issue= 4 |pages= 1104–17 |year= 1999 |pmid= 9927745 |doi=
*cite journal | author=Seidah NG, Mowla SJ, Hamelin J, "et al." |title=Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 4 |pages= 1321–6 |year= 1999 |pmid= 9990022 |doi=
*cite journal | author=Nagoshi E, Imamoto N, Sato R, Yoneda Y |title=Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip. |journal=Mol. Biol. Cell |volume=10 |issue= 7 |pages= 2221–33 |year= 1999 |pmid= 10397761 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=DeBose-Boyd RA, Brown MS, Li WP, "et al." |title=Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. |journal=Cell |volume=99 |issue= 7 |pages= 703–12 |year= 2000 |pmid= 10619424 |doi=
*cite journal | author=Kotzka J, Müller-Wieland D, Roth G, "et al." |title=Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade. |journal=J. Lipid Res. |volume=41 |issue= 1 |pages= 99–108 |year= 2000 |pmid= 10627507 |doi=
*cite journal | author=Yang T, Goldstein JL, Brown MS |title=Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29881–6 |year= 2000 |pmid= 10896675 |doi= 10.1074/jbc.M005439200

External links

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