- GABPA
GA binding protein transcription factor, alpha subunit 60kDa, also known as GABPA, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.cite web | title = Entrez Gene: GABPA GA binding protein transcription factor, alpha subunit 60kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2551| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Chrast R, Chen H, Morris MA, Antonarakis SE |title=Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21. |journal=Genomics |volume=28 |issue= 1 |pages= 119–22 |year= 1995 |pmid= 7590737 |doi= 10.1006/geno.1995.1117
*cite journal | author=Sawada J, Goto M, Watanabe H, "et al." |title=Regional mapping of two subunits of transcription factor E4TF1 to human chromosome. |journal=Jpn. J. Cancer Res. |volume=86 |issue= 1 |pages= 10–2 |year= 1995 |pmid= 7737900 |doi=
*cite journal | author=Gugneja S, Virbasius JV, Scarpulla RC |title=Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 102–11 |year= 1995 |pmid= 7799916 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Watanabe H, Sawada J, Yano K, "et al." |title=cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1385–91 |year= 1993 |pmid= 8441384 |doi=
*cite journal | author=Goto M, Shimizu T, Sawada J, "et al." |title=Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3. |journal=Gene |volume=166 |issue= 2 |pages= 337–8 |year= 1996 |pmid= 8543189 |doi=
*cite journal | author=Sawa C, Goto M, Suzuki F, "et al." |title=Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation. |journal=Nucleic Acids Res. |volume=24 |issue= 24 |pages= 4954–61 |year= 1997 |pmid= 9016666 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Batchelor AH, Piper DE, de la Brousse FC, "et al." |title=The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. |journal=Science |volume=279 |issue= 5353 |pages= 1037–41 |year= 1998 |pmid= 9461436 |doi=
*cite journal | author=Suzuki F, Goto M, Sawa C, "et al." |title=Functional interactions of transcription factor human GA-binding protein subunits. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29302–8 |year= 1998 |pmid= 9792629 |doi=
*cite journal | author=Itoh K, Wakabayashi N, Katoh Y, "et al." |title=Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 76–86 |year= 1999 |pmid= 9887101 |doi=
*cite journal | author=Bannert N, Avots A, Baier M, "et al." |title=GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 4 |pages= 1541–6 |year= 1999 |pmid= 9990060 |doi=
*cite journal | author=Sawada J, Simizu N, Suzuki F, "et al." |title=Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35475–82 |year= 2000 |pmid= 10585419 |doi=
*cite journal | author=Guo A, Nie F, Wong-Riley M |title=Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system. |journal=J. Comp. Neurol. |volume=417 |issue= 2 |pages= 221–32 |year= 2000 |pmid= 10660899 |doi=
*cite journal | author=Vogel JL, Kristie TM |title=The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. |journal=EMBO J. |volume=19 |issue= 4 |pages= 683–90 |year= 2000 |pmid= 10675337 |doi= 10.1093/emboj/19.4.683
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Galvagni F, Capo S, Oliviero S |title=Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter. |journal=J. Mol. Biol. |volume=306 |issue= 5 |pages= 985–96 |year= 2001 |pmid= 11237613 |doi= 10.1006/jmbi.2000.4335
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dhakshinamoorthy S, Porter AG |title=Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20096–107 |year= 2004 |pmid= 14985350 |doi= 10.1074/jbc.M312492200
*cite journal | author=Shen G, Hebbar V, Nair S, "et al." |title=Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23052–60 |year= 2004 |pmid= 15020583 |doi= 10.1074/jbc.M401368200PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
