BCL11A

B-cell CLL/lymphoma 11A (zinc finger protein), also known as BCL11A, is a human gene.cite web | title = Entrez Gene: BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53335| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Five alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.cite web | title = Entrez Gene: BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53335| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Avram D, Fields A, Pretty On Top K, "et al." |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315–22 |year= 2000 |pmid= 10744719 |doi=
*cite journal | author=Nakamura T, Yamazaki Y, Saiki Y, "et al." |title=Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3178–86 |year= 2000 |pmid= 10757802 |doi=
*cite journal | author=Saiki Y, Yamazaki Y, Yoshida M, "et al." |title=Human EVI9, a homologue of the mouse myeloid leukemia gene, is expressed in the hematopoietic progenitors and down-regulated during myeloid differentiation of HL60 cells. |journal=Genomics |volume=70 |issue= 3 |pages= 387–91 |year= 2001 |pmid= 11161790 |doi= 10.1006/geno.2000.6385
*cite journal | author=Nagase T, Nakayama M, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=
*cite journal | author=Satterwhite E, Sonoki T, Willis TG, "et al." |title=The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. |journal=Blood |volume=98 |issue= 12 |pages= 3413–20 |year= 2001 |pmid= 11719382 |doi=
*cite journal | author=Martín-Subero JI, Gesk S, Harder L, "et al." |title=Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. |journal=Blood |volume=99 |issue= 4 |pages= 1474–7 |year= 2002 |pmid= 11830502 |doi=
*cite journal | author=Küppers R, Sonoki T, Satterwhite E, "et al." |title=Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene. |journal=Leukemia |volume=16 |issue= 5 |pages= 937–9 |year= 2002 |pmid= 11986957 |doi= 10.1038/sj.leu.2402480
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Senawong T, Peterson VJ, Leid M |title=BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. |journal=Arch. Biochem. Biophys. |volume=434 |issue= 2 |pages= 316–25 |year= 2005 |pmid= 15639232 |doi= 10.1016/j.abb.2004.10.028
*cite journal | author=Liu H, Ippolito GC, Wall JK, "et al." |title=Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells. |journal=Mol. Cancer |volume=5 |issue= |pages= 18 |year= 2006 |pmid= 16704730 |doi= 10.1186/1476-4598-5-18
*cite journal | author=Weniger MA, Pulford K, Gesk S, "et al." |title=Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma. |journal=Leukemia |volume=20 |issue= 10 |pages= 1880–2 |year= 2006 |pmid= 16871282 |doi= 10.1038/sj.leu.2404324
*cite journal | author=Szafranski K, Schindler S, Taudien S, "et al." |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |journal= |volume=8 |issue= 8 |pages= R154 |year= |pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154

External links

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