NUP54

Nucleoporin 54kDa
Identifiers
Symbols	NUP54; MGC13407
External IDs	OMIM: 607607 MGI: 1920460 HomoloGene: 41169 GeneCards: NUP54 Gene
Gene Ontology Molecular function • nucleocytoplasmic transporter activity Cellular component • nucleus • nuclear envelope • nuclear envelope • nuclear pore • nucleoplasm • cytoplasm • membrane • nuclear membrane Biological process • carbohydrate metabolic process • protein targeting • hexose transport • regulation of glucose transport • protein transport • glucose transport • viral reproduction • mRNA transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53371	269113
Ensembl	ENSG00000138750	ENSMUSG00000034826
UniProt	Q7Z3B4	Q8BTS4
RefSeq (mRNA)	NM_017426	NM_183392.2
RefSeq (protein)	NP_059122	NP_899248.1
Location (UCSC)	Chr 4: 77.04 – 77.07 Mb	Chr 5: 92.84 – 92.86 Mb
PubMed search	[1]	[2]

Nucleoporin p54 is a protein that in humans is encoded by the NUP54 gene.^[1][2]

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.^[2]

References

1. ^ Hu T, Guan T, Gerace L (Sep 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J Cell Biol 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120945. 
2. ^ ^{a b} "Entrez Gene: NUP54 nucleoporin 54kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53371. 

Further reading

• Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558. 
• Bodoor K, Shaikh S, Enarson P, (1999). "Function and assembly of nuclear pore complex proteins". Biochem. Cell Biol. 77 (4): 321–329. doi:10.1139/bcb-77-4-321. PMID 10546895. 
• Finlay DR, Meier E, Bradley P, (1991). "A complex of nuclear pore proteins required for pore function". J. Cell Biol. 114 (1): 169–183. doi:10.1083/jcb.114.1.169. PMC 2289063. PMID 2050741. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2289063. 
• Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–261. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120351. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Guan T, Müller S, Klier G, (1996). "Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex". Mol. Biol. Cell 6 (11): 1591–1603. PMC 301313. PMID 8589458. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=301313. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Popov S, Rexach M, Ratner L, (1998). "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex". J. Biol. Chem. 273 (21): 13347–13352. doi:10.1074/jbc.273.21.13347. PMID 9582382. 
• Hu RM, Han ZG, Song HD, (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901. 
• Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.