- Nucleoporin
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Nucleoporin 220px Structure of nucleoporin Nup107/Nup133 interaction complex, delta finger mutant. Identifiers Symbol Nucleoporin Pfam PF03177 InterPro IPR004870 Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary The nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex.[1] The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nuclear pores in turn allow the transport of water-soluble molecules across the nuclear envelope.
The proteins involved are named for their molecular weight (in kilo Daltons), and include the following:
- NUP35, NUP37, NUP43, NUP50
- NUP54, NUP62, NUP85, NUP88, NUP93, NUP98
- NUP107, NUP133, NUP153, NUP155, NUP160, NUP188
- NUP205, NUP210, NUP214
References
- ^ Doye V, Hurt E (June 1997). "From nucleoporins to nuclear pore complexes". Curr. Opin. Cell Biol. 9 (3): 401–11. doi:10.1016/S0955-0674(97)80014-2. PMID 9159086.
External links
Structures of the cell nucleus / nuclear protein Envelope (membrane)/
nuclear laminaNucleolus Other Chromatin · Dot (PML body) · Paraspeckle
SMC protein: Cohesin (SMC1A, SMC1B, SMC3) · Condensin (NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NCAPH2, SMC2, SMC4) · DNA repair (SMC5, SMC6)
Transition nuclear protein: TNP1, TNP2
Nuclear matrix · Nucleoplasm · Nucleoskeleton · Nucleosol
see also transcription factors and intracellular receptorssee also nucleus diseases
B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)Categories:- Biochemistry stubs
- Protein families
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