NUP107

Nucleoporin 107kDa
Rendering based on PDB 3CQC.
Available structures PDB 3CQC, 3CQG, 3I4R
Identifiers
Symbols	NUP107; NUP84
External IDs	OMIM: 607617 MGI: 2143854 HomoloGene: 5555 GeneCards: NUP107 Gene
Gene Ontology Molecular function • nucleocytoplasmic transporter activity • protein binding Cellular component • kinetochore • condensed chromosome kinetochore • nucleus • nuclear envelope • nuclear envelope • nuclear pore • chromosome • cytosol • Nup107-160 complex • Nup107-160 complex Biological process • M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • carbohydrate metabolic process • mRNA export from nucleus • hexose transport • regulation of glucose transport • protein transport • glucose transport • viral reproduction • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57122	103468
Ensembl	ENSG00000111581	ENSMUSG00000052798
UniProt	P57740	Q3TT06
RefSeq (mRNA)	NM_020401	NM_134010.2
RefSeq (protein)	NP_065134	NP_598771.1
Location (UCSC)	Chr 12: 69.08 – 69.14 Mb	Chr 10: 117.19 – 117.23 Mb
PubMed search	[1]	[2]

Nuclear pore complex protein Nup107 is a protein that in humans is encoded by the NUP107 gene.^[1][2][3]

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[3]

Interactions

NUP107 has been shown to interact with NUP133.^[4][5]

References

1. ^ Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proc Natl Acad Sci U S A 100 (3): 981–5. doi:10.1073/pnas.252749899. PMC 298712. PMID 12552102. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298712. 
2. ^ Walther TC, Alves A, Pickersgill H, Loiodice I, Hetzer M, Galy V, Hulsmann BB, Kocher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. 
3. ^ ^{a b} "Entrez Gene: NUP107 nucleoporin 107kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57122. 
4. ^ Loïodice, Isabelle; Alves Annabelle, Rabut Gwénaël, Van Overbeek Megan, Ellenberg Jan, Sibarita Jean-Baptiste, Doye Valérie (Jul. 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell (United States) 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. ISSN 1059-1524. PMC 452587. PMID 15146057. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452587. 
5. ^ Belgareh, N; Rabut G, Baï S W, van Overbeek M, Beaudouin J, Daigle N, Zatsepina O V, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep. 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". J. Cell Biol. (United States) 154 (6): 1147–60. doi:10.1083/jcb.200101081. ISSN 0021-9525. PMC 2150808. PMID 11564755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150808. 

Further reading

• Bastos R, Ribas de Pouplana L, Enarson M, et al. (1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex.". J. Cell Biol. 137 (5): 989–1000. doi:10.1083/jcb.137.5.989. PMC 2136229. PMID 9166401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2136229. 
• Belgareh N, Rabut G, Baï SW, et al. (2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells.". J. Cell Biol. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150808. 
• Vasu S, Shah S, Orjalo A, et al. (2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.". J. Cell Biol. 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150853. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Walther TC, Askjaer P, Gentzel M, et al. (2003). "RanGTP mediates nuclear pore complex assembly.". Nature 424 (6949): 689–94. doi:10.1038/nature01898. PMID 12894213. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452587. 
• Krull S, Thyberg J, Björkroth B, et al. (2005). "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket.". Mol. Biol. Cell 15 (9): 4261–77. doi:10.1091/mbc.E04-03-0165. PMC 515357. PMID 15229283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515357. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Berke IC, Boehmer T, Blobel G, Schwartz TU (2005). "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex.". J. Cell Biol. 167 (4): 591–7. doi:10.1083/jcb.200408109. PMC 2172596. PMID 15557116. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172596. 
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365. 
• Orjalo AV, Arnaoutov A, Shen Z, et al. (2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly.". Mol. Biol. Cell 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMC 1593160. PMID 16807356. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1593160. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Glavy JS, Krutchinsky AN, Cristea IM, et al. (2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3811–6. doi:10.1073/pnas.0700058104. PMC 1820666. PMID 17360435. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1820666. 
• Zuccolo M, Alves A, Galy V, et al. (2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.". EMBO J. 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMC 1847668. PMID 17363900. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847668. 
• Boehmer T, Schwartz TU (2007). "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 9): 816–8. doi:10.1107/S1744309107040523. PMC 2376328. PMID 17768364. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2376328.