[cite web | title = Entrez Gene: TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7051| accessdate = ] ]Keratinocyte transglutaminase is a transglutaminase enzyme.
Pathology
A deficiency is associated with ichthyosis lamellaris. [cite journal |author=Hennies HC, Küster W, Wiebe V, Krebsová A, Reis A |title=Genotype/phenotype correlation in autosomal recessive lamellar ichthyosis |journal=Am. J. Hum. Genet. |volume=62 |issue=5 |pages=1052–61 |year=1998 |pmid=9545389 |doi=] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.
ee also
* Keratinocyte
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Phillips MA, Stewart BE, Rice RH |title=Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function. |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2282–6 |year= 1992 |pmid= 1346394 |doi=
*cite journal | author=Kim IG, McBride OW, Wang M, "et al." |title=Structure and organization of the human transglutaminase 1 gene. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7710–7 |year= 1992 |pmid= 1348508 |doi=
*cite journal | author=Polakowska RR, Eickbush T, Falciano V, "et al." |title=Organization and evolution of the human epidermal keratinocyte transglutaminase I gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4476–80 |year= 1992 |pmid= 1350092 |doi=
*cite journal | author=Schroeder WT, Thacher SM, Stewart-Galetka S, "et al." |title=Type I keratinocyte transglutaminase: expression in human skin and psoriasis. |journal=J. Invest. Dermatol. |volume=99 |issue= 1 |pages= 27–34 |year= 1992 |pmid= 1351505 |doi=
*cite journal | author=Yamanishi K, Inazawa J, Liew FM, "et al." |title=Structure of the gene for human transglutaminase 1. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17858–63 |year= 1992 |pmid= 1381356 |doi=
*cite journal | author=Kim HC, Idler WW, Kim IG, "et al." |title=The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones. |journal=J. Biol. Chem. |volume=266 |issue= 1 |pages= 536–9 |year= 1991 |pmid= 1670769 |doi=
*cite journal | author=Yamanishi K, Liew FM, Konishi K, "et al." |title=Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture. |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 3 |pages= 906–13 |year= 1991 |pmid= 1673840 |doi=
*cite journal | author=Polakowska R, Herting E, Goldsmith LA |title=Isolation of cDNA for human epidermal type I transglutaminase. |journal=J. Invest. Dermatol. |volume=96 |issue= 2 |pages= 285–8 |year= 1991 |pmid= 1704039 |doi=
*cite journal | author=Phillips MA, Stewart BE, Qin Q, "et al." |title=Primary structure of keratinocyte transglutaminase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9333–7 |year= 1991 |pmid= 1979171 |doi=
*cite journal | author=Candi E, Melino G, Mei G, "et al." |title=Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26382–90 |year= 1995 |pmid= 7592852 |doi=
*cite journal | author=Mariniello L, Esposito C, Di Pierro P, "et al." |title=Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro. |journal=Eur. J. Biochem. |volume=215 |issue= 1 |pages= 99–104 |year= 1993 |pmid= 7688299 |doi=
*cite journal | author=Russell LJ, DiGiovanna JJ, Rogers GR, "et al." |title=Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis. |journal=Nat. Genet. |volume=9 |issue= 3 |pages= 279–83 |year= 1995 |pmid= 7773290 |doi= 10.1038/ng0395-279
*cite journal | author=Huber M, Rettler I, Bernasconi K, "et al." |title=Mutations of keratinocyte transglutaminase in lamellar ichthyosis. |journal=Science |volume=267 |issue= 5197 |pages= 525–8 |year= 1995 |pmid= 7824952 |doi=
*cite journal | author=Amendola A, Lombardi G, Oliverio S, "et al." |title=HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. |journal=FEBS Lett. |volume=339 |issue= 3 |pages= 258–64 |year= 1994 |pmid= 7906657 |doi=
*cite journal | author=Kim SY, Kim IG, Chung SI, Steinert PM |title=The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 27979–86 |year= 1994 |pmid= 7961731 |doi=
*cite journal | author=Steinert PM, Kim SY, Chung SI, Marekov LN |title=The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes. |journal=J. Biol. Chem. |volume=271 |issue= 42 |pages= 26242–50 |year= 1996 |pmid= 8824274 |doi=
*cite journal | author=Laiho E, Ignatius J, Mikkola H, "et al." |title=Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population. |journal=Am. J. Hum. Genet. |volume=61 |issue= 3 |pages= 529–38 |year= 1997 |pmid= 9326318 |doi=
*cite journal | author=Tarcsa E, Marekov LN, Andreoli J, "et al." |title=The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27893–901 |year= 1997 |pmid= 9346937 |doi=
*cite journal | author=Petit E, Huber M, Rochat A, "et al." |title=Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 4 |pages= 218–28 |year= 1998 |pmid= 9359043 |doi=
*cite journal | author=Iwasaki W, Nagata K, Hatanaka H, "et al." |title=Solution structure of midkine, a new heparin-binding growth factor. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6936–46 |year= 1998 |pmid= 9384573 |doi= 10.1093/emboj/16.23.6936
External links
*
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