NCAPH

NCAPH
Non-SMC condensin I complex, subunit H
Identifiers
Symbols NCAPH; BRRN1; CAP-H; HCAP-H
External IDs OMIM602332 MGI2444777 HomoloGene5320 GeneCards: NCAPH Gene
RNA expression pattern
PBB GE NCAPH 212949 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23397 215387
Ensembl ENSG00000121152 ENSMUSG00000034906
UniProt Q15003 Q6ZQJ9
RefSeq (mRNA) NM_015341 NM_144818.3
RefSeq (protein) NP_056156 NP_659067.2
Location (UCSC) Chr 2:
97 – 97.04 Mb
Chr 2:
126.93 – 126.96 Mb
PubMed search [1] [2]

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene.[1][2] CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation

Function

CAP-H is a member of the barr protein family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. CAP-H is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.[2]

References

  1. ^ Cabello OA, Baldini A, Bhat M, Bellen H, Belmont JW (Feb 1998). "Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2". Genomics 46 (2): 311–3. doi:10.1006/geno.1997.5021. PMID 9417923. 
  2. ^ a b "Entrez Gene: NCAPH non-SMC condensin I complex, subunit H". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23397. 

Further reading


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Condensin — Condensins are large protein complexes that play a central role in chromosome assembly and segregation in eukaryotic cells. Contents 1 Subunit composition 2 Evolution 3 Subcellular localization and regulation …   Wikipedia

  • Cell nucleus — HeLa cells stained for the cell nucleus DNA with the Blue Hoechst dye. The central and rightmost cell are in interphase, thus their entire nuclei are labeled. On the left, a cell is going through mitosis and its DNA has condensed ready for… …   Wikipedia

  • Chromatin — The major structures in DNA compaction; DNA, the nucleosome, the 10nm beads on a string fibre, the 30nm fibre and the metaphase chromosome Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The… …   Wikipedia

  • Nuclear pore — Diagram of human cell nucleus. Nuclear pore labeled at bottom left …   Wikipedia

  • Nucleolus — The nucleolus is contained within the cell nucleus …   Wikipedia

  • Nucleoplasm — Similar to the cytoplasm of a cell, the nucleus contains nucleoplasm (nucleus sap) or karyoplasm. The nucleoplasm is one of the types of protoplasm, and it is enveloped by the nuclear membrane or nuclear envelope. The nucleoplasm is a highly… …   Wikipedia

  • Nuclear lamina — The nuclear lamina is a dense ( 30 to 100 nm thick) fibrillar network inside the nucleus of a eukaryotic cell. It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support, the nuclear lamina… …   Wikipedia

  • Cajal body — Nuclei of mouse cells (blue) containing Cajal bodies (green) visualized by fusion of p80/Coilin protein to GFP. Cajal bodies (CBs) are spherical sub organelles of 0.3 1.0 µm in diameter found in the nucleus of proliferative cells like embryonic… …   Wikipedia

  • Nuclear matrix — In biology, the nuclear matrix is the network of fibres found throughout the inside of a cell nucleus and is somewhat analogous to the cell cytoskeleton. However, in contrast to the cytoskeleton, the nuclear matrix has been proposed to be a… …   Wikipedia

  • Nucleolus organizer region — The nucleolus organizer region (NOR) or nucleolar organizer is a chromosomal region around which the nucleolus forms. This region is the particular part of a chromosome that is associated with a nucleolus after the nucleus divides. The region… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”