PTBP1

PTBP1

Polypyrimidine tract binding protein 1, also known as PTBP1, is a human gene.cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5725| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5725| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Ghetti A, Piñol-Roma S, Michael WM, "et al." |title=hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. |journal=Nucleic Acids Res. |volume=20 |issue= 14 |pages= 3671–8 |year= 1992 |pmid= 1641332 |doi=
*cite journal | author=Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA |title=Characterization of cDNAs encoding the polypyrimidine tract-binding protein. |journal=Genes Dev. |volume=5 |issue= 7 |pages= 1224–36 |year= 1991 |pmid= 1906035 |doi=
*cite journal | author=Patton JG, Mayer SA, Tempst P, Nadal-Ginard B |title=Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. |journal=Genes Dev. |volume=5 |issue= 7 |pages= 1237–51 |year= 1991 |pmid= 1906036 |doi=
*cite journal | author=Raimondi E, Romanelli MG, Moralli D, "et al." |title=Assignment of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein I (PTB) to chromosome 14q23-q24.1. |journal=Genomics |volume=27 |issue= 3 |pages= 553–5 |year= 1995 |pmid= 7558043 |doi= 10.1006/geno.1995.1093
*cite journal | author=Patton JG, Porro EB, Galceran J, "et al." |title=Cloning and characterization of PSF, a novel pre-mRNA splicing factor. |journal=Genes Dev. |volume=7 |issue= 3 |pages= 393–406 |year= 1993 |pmid= 8449401 |doi=
*cite journal | author=Wu-Baer F, Lane WS, Gaynor RB |title=Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4201–8 |year= 1996 |pmid= 8626763 |doi=
*cite journal | author=Black AC, Luo J, Chun S, "et al." |title=Specific binding of polypyrimidine tract binding protein and hnRNP A1 to HIV-1 CRS elements. |journal=Virus Genes |volume=12 |issue= 3 |pages= 275–85 |year= 1997 |pmid= 8883365 |doi=
*cite journal | author=Huang S, Deerinck TJ, Ellisman MH, Spector DL |title=The dynamic organization of the perinucleolar compartment in the cell nucleus. |journal=J. Cell Biol. |volume=137 |issue= 5 |pages= 965–74 |year= 1997 |pmid= 9166399 |doi=
*cite journal | author=Oh YL, Hahm B, Kim YK, "et al." |title=Determination of functional domains in polypyrimidine-tract-binding protein. |journal=Biochem. J. |volume=331 ( Pt 1) |issue= |pages= 169–75 |year= 1998 |pmid= 9512476 |doi=
*cite journal | author=Hahm B, Cho OH, Kim JE, "et al." |title=Polypyrimidine tract-binding protein interacts with HnRNP L. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 401–6 |year= 1998 |pmid= 9563502 |doi=
*cite journal | author=Meissner M, Dechat T, Gerner C, "et al." |title=Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB. |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 559–66 |year= 2000 |pmid= 10653975 |doi=
*cite journal | author=Kim JH, Hahm B, Kim YK, "et al." |title=Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. |journal=J. Mol. Biol. |volume=298 |issue= 3 |pages= 395–405 |year= 2000 |pmid= 10772858 |doi= 10.1006/jmbi.2000.3687
*cite journal | author=Conte MR, Grüne T, Ghuman J, "et al." |title=Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold. |journal=EMBO J. |volume=19 |issue= 12 |pages= 3132–41 |year= 2000 |pmid= 10856256 |doi= 10.1093/emboj/19.12.3132
*cite journal | author=Markovtsov V, Nikolic JM, Goldman JA, "et al." |title=Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7463–79 |year= 2000 |pmid= 11003644 |doi=
*cite journal | author=Romanelli MG, Lorenzi P, Morandi C |title=Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene. |journal=Gene |volume=255 |issue= 2 |pages= 267–72 |year= 2000 |pmid= 11024286 |doi=
*cite journal | author=de Vries H, Rüegsegger U, Hübner W, "et al." |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895
*cite journal | author=Zang WQ, Li B, Huang PY, "et al." |title=Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. |journal=J. Virol. |volume=75 |issue= 22 |pages= 10779–86 |year= 2001 |pmid= 11602719 |doi= 10.1128/JVI.75.22.10779-10786.2001
*cite journal | author=Hüttelmaier S, Illenberger S, Grosheva I, "et al." |title=Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 775–86 |year= 2002 |pmid= 11724819 |doi= 10.1083/jcb.200105044
*cite journal | author=Kamath RV, Leary DJ, Huang S |title=Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export. |journal=Mol. Biol. Cell |volume=12 |issue= 12 |pages= 3808–20 |year= 2002 |pmid= 11739782 |doi=

PBB_Controls
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