- Homeobox A10
Homeobox A10, also known as HOXA10, is a human
gene .cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = ]PBB_Summary
section_title =
summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = ]ee also
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Homeobox References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Eun Kwon H, Taylor HS |title=The role of HOX genes in human implantation. |journal=Ann. N. Y. Acad. Sci. |volume=1034 |issue= |pages= 1–18 |year= 2005 |pmid= 15731295 |doi= 10.1196/annals.1335.001
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=Lowney P, Corral J, Detmer K, "et al." |title=A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. |journal=Nucleic Acids Res. |volume=19 |issue= 12 |pages= 3443–9 |year= 1991 |pmid= 1676505 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Shen WF, Largman C, Lowney P, "et al." |title=Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8536–40 |year= 1989 |pmid= 2573064 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Sauvageau G, Lansdorp PM, Eaves CJ, "et al." |title=Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12223–7 |year= 1995 |pmid= 7527557 |doi=
*cite journal | author=Lawrence HJ, Sauvageau G, Ahmadi N, "et al." |title=Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. |journal=Exp. Hematol. |volume=23 |issue= 11 |pages= 1160–6 |year= 1995 |pmid= 7556525 |doi=
*cite journal | author=Satokata I, Benson G, Maas R |title=Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. |journal=Nature |volume=374 |issue= 6521 |pages= 460–3 |year= 1995 |pmid= 7700356 |doi= 10.1038/374460a0
*cite journal | author=Castronovo V, Kusaka M, Chariot A, "et al." |title=Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. |journal=Biochem. Pharmacol. |volume=47 |issue= 1 |pages= 137–43 |year= 1994 |pmid= 7906121 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Thorsteinsdottir U, Sauvageau G, Hough MR, "et al." |title=Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. |journal=Mol. Cell. Biol. |volume=17 |issue= 1 |pages= 495–505 |year= 1997 |pmid= 8972230 |doi=
*cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, "et al." |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448–58 |year= 1997 |pmid= 9343407 |doi=
*cite journal | author=Taylor HS, Vanden Heuvel GB, Igarashi P |title=A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. |journal=Biol. Reprod. |volume=57 |issue= 6 |pages= 1338–45 |year= 1998 |pmid= 9408238 |doi=
*cite journal | author=Taylor HS, Arici A, Olive D, Igarashi P |title=HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. |journal=J. Clin. Invest. |volume=101 |issue= 7 |pages= 1379–84 |year= 1998 |pmid= 9525980 |doi=
*cite journal | author=Kawagoe H, Humphries RK, Blair A, "et al." |title=Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. |journal=Leukemia |volume=13 |issue= 5 |pages= 687–98 |year= 1999 |pmid= 10374871 |doi=
*cite journal | author=Eklund EA, Jalava A, Kakar R |title=Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20117–26 |year= 2000 |pmid= 10766757 |doi= 10.1074/jbc.M907915199
*cite journal | author=Buske C, Feuring-Buske M, Antonchuk J, "et al." |title=Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. |journal=Blood |volume=97 |issue= 8 |pages= 2286–92 |year= 2001 |pmid= 11290589 |doi=
*cite journal | author=Cermik D, Karaca M, Taylor HS |title=HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 3387–92 |year= 2001 |pmid= 11443215 |doi=
*cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509–22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001External links
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