RFX1

Regulatory factor X, 1 (influences HLA class II expression), also known as RFX1, is a human gene.cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5989| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5989| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pugliatti L, Derré J, Berger R, "et al." |title=The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19. |journal=Genomics |volume=13 |issue= 4 |pages= 1307–10 |year= 1992 |pmid= 1505960 |doi=
*cite journal | author=Herrero Sanchez C, Reith W, Silacci P, Mach B |title=The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. |journal=Mol. Cell. Biol. |volume=12 |issue= 9 |pages= 4076–83 |year= 1992 |pmid= 1508204 |doi=
*cite journal | author=Reith W, Herrero-Sanchez C, Kobr M, "et al." |title=MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. |journal=Genes Dev. |volume=4 |issue= 9 |pages= 1528–40 |year= 1991 |pmid= 2253877 |doi=
*cite journal | author=Sáfrány G, Perry RP |title=Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. |journal=Gene |volume=132 |issue= 2 |pages= 279–83 |year= 1993 |pmid= 8224874 |doi=
*cite journal | author=Reith W, Ucla C, Barras E, "et al." |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230–44 |year= 1994 |pmid= 8289803 |doi=
*cite journal | author=Siegrist CA, Durand B, Emery P, "et al." |title=RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6375–84 |year= 1993 |pmid= 8413236 |doi=
*cite journal | author=Emery P, Durand B, Mach B, Reith W |title=RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. |journal=Nucleic Acids Res. |volume=24 |issue= 5 |pages= 803–7 |year= 1996 |pmid= 8600444 |doi=
*cite journal | author=Doyle J, Hoffman S, Ucla C, "et al." |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227–30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343
*cite journal | author=Agami R, Shaul Y |title=The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes. |journal=Oncogene |volume=16 |issue= 14 |pages= 1779–88 |year= 1998 |pmid= 9583676 |doi= 10.1038/sj.onc.1201708
*cite journal | author=Katan-Khaykovich Y, Shaul Y |title=RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24504–12 |year= 1998 |pmid= 9733744 |doi=
*cite journal | author=Iwama A, Pan J, Zhang P, "et al." |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940–50 |year= 1999 |pmid= 10330134 |doi=
*cite journal | author=Zajac-Kaye M, Ben-Baruch N, Kastanos E, "et al." |title=Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells. |journal=Biochem. J. |volume=345 Pt 3 |issue= |pages= 535–41 |year= 2000 |pmid= 10642512 |doi=
*cite journal | author=Katan-Khaykovich Y, Shaul Y |title=Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism. |journal=Eur. J. Biochem. |volume=268 |issue= 10 |pages= 3108–16 |year= 2001 |pmid= 11358531 |doi=
*cite journal | author=Morotomi-Yano K, Yano K, Saito H, "et al." |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836–42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200
*cite journal | author=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926–37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200
*cite journal | author=Nakayama A, Murakami H, Maeyama N, "et al." |title=Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 233–40 |year= 2003 |pmid= 12411430 |doi= 10.1074/jbc.M209574200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Norquay LD, Yang X, Sheppard P, "et al." |title=RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin. |journal=Mol. Endocrinol. |volume=17 |issue= 6 |pages= 1027–38 |year= 2003 |pmid= 12624117 |doi= 10.1210/me.2003-0025
*cite journal | author=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482–9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101

External links

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