- TBX19
T-box 19, also known as TBX19, is a human
gene .PBB_Summary
section_title =
summary_text = This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. [cite web | title = Entrez Gene: TBX19 T-box 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9095| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Asteria C |title=T-box and isolated ACTH deficiency. |journal=Eur. J. Endocrinol. |volume=146 |issue= 4 |pages= 463–5 |year= 2002 |pmid= 11916612 |doi=External links
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PBB_Controls
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