Small ubiquitin-related modifier 1

Small ubiquitin-related modifier 1

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae), also known as SUMO1, is a human gene.

PBB_Summary
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summary_text = This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.cite web | title = Entrez Gene: SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7341| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cookson MR |title=Pathways to Parkinsonism. |journal=Neuron |volume=37 |issue= 1 |pages= 7–10 |year= 2003 |pmid= 12526767 |doi=
*cite journal | author=Boddy MN, Howe K, Etkin LD, "et al." |title=PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. |journal=Oncogene |volume=13 |issue= 5 |pages= 971–82 |year= 1996 |pmid= 8806687 |doi=
*cite journal | author=Shen Z, Pardington-Purtymun PE, Comeaux JC, "et al." |title=UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. |journal=Genomics |volume=36 |issue= 2 |pages= 271–9 |year= 1997 |pmid= 8812453 |doi= 10.1006/geno.1996.0462
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Okura T, Gong L, Kamitani T, "et al." |title=Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin. |journal=J. Immunol. |volume=157 |issue= 10 |pages= 4277–81 |year= 1996 |pmid= 8906799 |doi=
*cite journal | author=Shen Z, Pardington-Purtymun PE, Comeaux JC, "et al." |title=Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system. |journal=Genomics |volume=37 |issue= 2 |pages= 183–6 |year= 1997 |pmid= 8921390 |doi= 10.1006/geno.1996.0540
*cite journal | author=Matunis MJ, Coutavas E, Blobel G |title=A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. |journal=J. Cell Biol. |volume=135 |issue= 6 Pt 1 |pages= 1457–70 |year= 1997 |pmid= 8978815 |doi=
*cite journal | author=Mahajan R, Delphin C, Guan T, "et al." |title=A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. |journal=Cell |volume=88 |issue= 1 |pages= 97–107 |year= 1997 |pmid= 9019411 |doi=
*cite journal | author=Lapenta V, Chiurazzi P, van der Spek P, "et al." |title=SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. |journal=Genomics |volume=40 |issue= 2 |pages= 362–6 |year= 1997 |pmid= 9119407 |doi= 10.1006/geno.1996.4556
*cite journal | author=Kamitani T, Nguyen HP, Yeh ET |title=Preferential modification of nuclear proteins by a novel ubiquitin-like molecule. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14001–4 |year= 1997 |pmid= 9162015 |doi=
*cite journal | author=Mahajan R, Gerace L, Melchior F |title=Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. |journal=J. Cell Biol. |volume=140 |issue= 2 |pages= 259–70 |year= 1998 |pmid= 9442102 |doi=
*cite journal | author=Howe K, Williamson J, Boddy N, "et al." |title=The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes. |journal=Genomics |volume=47 |issue= 1 |pages= 92–100 |year= 1998 |pmid= 9465300 |doi= 10.1006/geno.1997.5091
*cite journal | author=Bayer P, Arndt A, Metzger S, "et al." |title=Structure determination of the small ubiquitin-related modifier SUMO-1. |journal=J. Mol. Biol. |volume=280 |issue= 2 |pages= 275–86 |year= 1998 |pmid= 9654451 |doi= 10.1006/jmbi.1998.1839
*cite journal | author=Desterro JM, Rodriguez MS, Hay RT |title=SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 233–9 |year= 1998 |pmid= 9734360 |doi=
*cite journal | author=Juo P, Kuo CJ, Yuan J, Blenis J |title=Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. |journal=Curr. Biol. |volume=8 |issue= 18 |pages= 1001–8 |year= 1998 |pmid= 9740801 |doi=
*cite journal | author=Kamitani T, Kito K, Nguyen HP, "et al." |title=Identification of three major sentrinization sites in PML. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26675–82 |year= 1998 |pmid= 9756909 |doi=
*cite journal | author=Duprez E, Saurin AJ, Desterro JM, "et al." |title=SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. |journal=J. Cell. Sci. |volume=112 ( Pt 3) |issue= |pages= 381–93 |year= 1999 |pmid= 9885291 |doi=
*cite journal | author=Chen A, Mannen H, Li SS |title=Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 6 |pages= 1161–74 |year= 1999 |pmid= 9891849 |doi=
*cite journal | author=Okuma T, Honda R, Ichikawa G, "et al." |title=In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 693–8 |year= 1999 |pmid= 9920803 |doi= 10.1006/bbrc.1998.9995
*cite journal | author=Liou ML, Liou HC |title=The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10145–53 |year= 1999 |pmid= 10187798 |doi=

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