NEUROG1

Neurogenin 1
Identifiers
Symbols	NEUROG1; AKA; Math4C; NEUROD3; bHLHa6; ngn1
External IDs	OMIM: 601726 MGI: 107754 HomoloGene: 4490 GeneCards: NEUROG1 Gene
Gene Ontology Molecular function • transcription factor binding transcription factor activity • DNA binding • sequence-specific DNA binding transcription factor activity • E-box binding Cellular component • nucleus • perikaryon Biological process • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • multicellular organismal development • nervous system development • positive regulation of exit from mitosis • inner ear morphogenesis • cell fate commitment • positive regulation of neuron differentiation • positive regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4762	18014
Ensembl	ENSG00000181965	ENSMUSG00000048904
UniProt	Q92886	P70660
RefSeq (mRNA)	NM_006161.2	NM_010896.2
RefSeq (protein)	NP_006152.2	NP_035026.1
Location (UCSC)	Chr 5: 134.87 – 134.87 Mb	Chr 13: 56.35 – 56.35 Mb
PubMed search	[1]	[2]

Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.^[1][2]

Interactions

NEUROG1 has been shown to interact with CREB-binding protein^[3] and Mothers against decapentaplegic homolog 1.^[3]

References

1. ^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Apr 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405. 
2. ^ "Entrez Gene: NEUROG1 neurogenin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4762. 
3. ^ ^{a b} Sun, Y; Nadal-Vicens M, Misono S, Lin M Z, Zubiaga A, Hua X, Fan G, Greenberg M E (Feb. 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell (United States) 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. ISSN 0092-8674. PMID 11239394. 

Further reading

• McCormick MB, Tamimi RM, Snider L, et al. (1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.". Mol. Cell. Biol. 16 (10): 5792–800. PMC 231580. PMID 8816493. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231580. 
• Sun Y, Nadal-Vicens M, Misono S, et al. (2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.". Cell 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394. 
• Franklin A, Kao A, Tapscott S, Unis A (2002). "NeuroD homologue expression during cortical development in the human brain.". J. Child Neurol. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Kim S, Ghil SH, Kim SS, et al. (2004). "Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells.". Exp. Mol. Med. 34 (6): 469–75. PMID 12526089. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Fanous AH, Chen X, Wang X, et al. (2007). "Association between the 5q31.1 gene neurogenin1 and schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 207–14. doi:10.1002/ajmg.b.30423. PMID 17044100.