Steven J. Burakoff

Steven J. Burakoff, MD, is a cancer specialist and the author of both "Therepeutic Immunology" (2001) and "Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment" (1990).

Biography

Burakoff is the Director of the Mount Sinai Medical Center’s Cancer Institute, which was created in 2007 to focus on translational medicine.

Before joining Mount Sinai, he was recruited by NYU to revitalize the research and treatment mission of NYU's Cancer Institute, which during his tenure experienced a 31 percent growth and a 50 percent increase in NCI funding. [ [http://www.newswise.com/articles/view/535307/ NewsWise – Steven Burakoff Named Director of Mount Sinai Medical Center’s Cancer Institute] retrieved April 29, 2008]

He completed a residency in medicine at New York Hospital-Cornell Medical Center and pursued fellowships in immunology at both Rockefeller University and Harvard Medical School.

Awards

*Harvard Medical School Excellence in Mentoring Award

Appointments and positions

* Director of The Mount Sinai Medical Center’s Cancer Institute [http://www.mountsinai.org]
* Formerly Laura and Isaac Perlmutter Professor, New York University School of Medicine
* Past Director, New York University Cancer Institute
* Past Director, Skirball Institute of Biomolecular Medicine, New York University School of Medicine [ [http://saturn.med.nyu.edu/research/mp/burakofflab/members/burakoff.html Skirball Institute - Steven Burakoff Laboratory] retrieved April 28, 2008]
* Past Chair of Pediatric Oncology at the Dana-Farber Cancer Institute
* Formerly Margaret M. Dyson Professor of Pediatrics at the Harvard Medical School
* Former Ted Williams Senior Investigator at the Dana-Farber Cancer Institute
* Former Member, Board of Trustees of the Dana-Farber Cancer Institute
* Board of Directors, Pharmacopeia Drug Discovery, Inc. [ [http://www.pharmacopeia.com/wt/page/bod_sburakoff Pharmacopeia: Board of Directors] retrieved April 28, 2008]

Education

* Lehigh University with a Bachelor of Science degree
* Master’s degree from Queens College
* M.D. from Albany Medical College
* Honorary Master’s of Science Degree from Harvard University

Publications

Books

* Strom TB, Austen KF, Burakoff SJ. "Therepeutic Immunology." Wiley-Blackwell, 2001 ISBN 0-632-04359-8

* Ferrara JLM, Deeg HJ, Burakoff SJ. "Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment." Marcel Dekker, 1990 ISBN 0-8247-9728-0

Other publications (partial list)

* [http://www.ncbi.nlm.nih.gov/pubmed/18586679?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction."] Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ. J Biol Chem. 2008
* [http://www.ncbi.nlm.nih.gov/pubmed/18523251?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation."] Jin YJ, Cai CY, Zhang X, Burakoff SJ. J Immunol. 2008
* [http://www.ncbi.nlm.nih.gov/pubmed/17895239?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway."] Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ. The journal of biological chemistry, 2007

* [http://www.ncbi.nlm.nih.gov/pubmed/17319736?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "From bytes to bedside: data integration and computational biology for translational cancer research."] Mathew JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AM, Sander C, Burakoff SJ, Mishra B. PLoS computational biology, 2007

* [http://www.ncbi.nlm.nih.gov/pubmed/17056525?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "A CD8/Lck transgene is able to drive thymocyte differentiation."] Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. Journal of immunology, 2006

* [http://www.ncbi.nlm.nih.gov/pubmed/16116206?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent."] Jin YJ, Cai CY, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. Journal of immunology, 2005

* [http://www.ncbi.nlm.nih.gov/pubmed/15494497?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "CD4 phosphorylation partially reverses Nef down-regulation of CD4."] Jin YJ, Zhang X, Boursiquot JG, Burakoff SJ. Journal of immunology, 2004

* [http://www.ncbi.nlm.nih.gov/pubmed/15231866?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells."] Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D, Modiano JF. The journal of pharmacology and experimental theraputics, 2004

* [http://www.ncbi.nlm.nih.gov/pubmed/15205258?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness."] Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd A, Doctrow SR, Burakoff SJ. Blood, 2004

* [http://www.ncbi.nlm.nih.gov/pubmed/15307178?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing."] Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. European journal of immunology, 2004

* [http://www.ncbi.nlm.nih.gov/pubmed/15205666?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model."] Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ. Journal of the American society of blood and marrow transplantation, 2004

* [http://www.ncbi.nlm.nih.gov/pubmed/14573608?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum "Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity."] Slavik JM, Lim DG, Burakoff SJ, Hafler DA., Journal of biological chemistry, 2004

References

External links

* [http://www.mountsinai.org Mount Sinai Hospital homepage]
* [http://www.mssm.edu/ Mount Sinai School of Medicine]