Nkx2-2as

NK2 transcription factor related, locus 2 (Drosophila), antisense
Identifiers
Organism	mouse
Symbol	Nkx2-2as
Entrez	100313531
RefSeq (mRNA)	NR_030769
Other data
Chromosome	2: 146.99 - 147.18 Mb

Nkx2-2as (Nkx2-2 antisense) is a long non-coding RNA. It is located in the cytoplasm of the cell. Nkx2-2as is involved in Neural development. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox gene Nkx2-2 and enhances induction of the differentiation of oligodendrocytes.^[1][2][3][4] Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes. ^[1][2]

See also

• Long non-coding RNA

References

1. ^ ^{a b} Tochitani S, Hayashizaki Y (August 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochem. Biophys. Res. Commun. 372 (4): 691–6. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132. 
2. ^ ^{a b} Szyma, .; Nacute, .; Ski, M.; Barciszewski, J. (2009), "Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System", Therapeutic Ribonucleic Acids in Brain Tumors: 453–470, http://www.springerlink.com/index/l4016j727530qm70.pdf, retrieved 2011-03-25 
3. ^ Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF (2010). "Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation.". BMC Neurosci 11: 14. PMID 20137068. 
4. ^ Qureshi IA, Mattick JS, Mehler MF (2010). "Long non-coding RNAs in nervous system function and disease.". Brain Res 1338: 20–35. doi:10.1016/j.brainres.2010.03.110. PMC 2883659. PMID 20380817. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2883659. 

Further reading

• Mattick JS (April 2009). "The genetic signatures of noncoding RNAs". PLoS Genet. 5 (4): e1000459. doi:10.1371/journal.pgen.1000459. PMC 2667263. PMID 19390609. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2667263. 

External links

• MGI entry for Nkx2-2as