BTRC (gene)

Beta-transducin repeat containing, also known as BTRC, is a human gene.cite web | title = Entrez Gene: BTRC beta-transducin repeat containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8945| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.cite web | title = Entrez Gene: BTRC beta-transducin repeat containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8945| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maniatis T |title=A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. |journal=Genes Dev. |volume=13 |issue= 5 |pages= 505–10 |year= 1999 |pmid= 10072378 |doi=
*cite journal | author=Li L, Li HS, Pauza CD, "et al." |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Margottin F, Bour SP, Durand H, "et al." |title=A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. |journal=Mol. Cell |volume=1 |issue= 4 |pages= 565–74 |year= 1998 |pmid= 9660940 |doi=
*cite journal | author=Yaron A, Hatzubai A, Davis M, "et al." |title=Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. |journal=Nature |volume=396 |issue= 6711 |pages= 590–4 |year= 1999 |pmid= 9859996 |doi= 10.1038/25159
*cite journal | author=Winston JT, Strack P, Beer-Romero P, "et al." |title=The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 270–83 |year= 1999 |pmid= 9990852 |doi=
*cite journal | author=Spencer E, Jiang J, Chen ZJ |title=Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 284–94 |year= 1999 |pmid= 9990853 |doi=
*cite journal | author=Kitagawa M, Hatakeyama S, Shirane M, "et al." |title=An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. |journal=EMBO J. |volume=18 |issue= 9 |pages= 2401–10 |year= 1999 |pmid= 10228155 |doi= 10.1093/emboj/18.9.2401
*cite journal | author=Fujiwara T, Suzuki M, Tanigami A, "et al." |title=The BTRC gene, encoding a human F-box/WD40-repeat protein, maps to chromosome 10q24-q25. |journal=Genomics |volume=58 |issue= 1 |pages= 104–5 |year= 1999 |pmid= 10331953 |doi= 10.1006/geno.1999.5792
*cite journal | author=Wu C, Ghosh S |title=beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29591–4 |year= 1999 |pmid= 10514424 |doi=
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Stone DM, Murone M, Luoh S, "et al." |title=Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. |journal=J. Cell. Sci. |volume=112 ( Pt 23) |issue= |pages= 4437–48 |year= 2000 |pmid= 10564661 |doi=
*cite journal | author=Suzuki H, Chiba T, Suzuki T, "et al." |title=Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2877–84 |year= 2000 |pmid= 10644755 |doi=
*cite journal | author=Read MA, Brownell JE, Gladysheva TB, "et al." |title=Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2326–33 |year= 2000 |pmid= 10713156 |doi=
*cite journal | author=Sadot E, Simcha I, Iwai K, "et al." |title=Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system. |journal=Oncogene |volume=19 |issue= 16 |pages= 1992–2001 |year= 2000 |pmid= 10803460 |doi= 10.1038/sj.onc.1203519
*cite journal | author=Chiaur DS, Murthy S, Cenciarelli C, "et al." |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255–8 |year= 2000 |pmid= 10828603 |doi=
*cite journal | author=Orian A, Gonen H, Bercovich B, "et al." |title=SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2580–91 |year= 2000 |pmid= 10835356 |doi= 10.1093/emboj/19.11.2580
*cite journal | author=Strack P, Caligiuri M, Pelletier M, "et al." |title=SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4. |journal=Oncogene |volume=19 |issue= 31 |pages= 3529–36 |year= 2000 |pmid= 10918611 |doi= 10.1038/sj.onc.1203647
*cite journal | author=Kleijnen MF, Shih AH, Zhou P, "et al." |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409–19 |year= 2000 |pmid= 10983987 |doi=

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