PIAS3

PIAS3

Protein inhibitor of activated STAT, 3, also known as PIAS3, is a human gene.cite web | title = Entrez Gene: PIAS3 protein inhibitor of activated STAT, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10401| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.cite web | title = Entrez Gene: PIAS3 protein inhibitor of activated STAT, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10401| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chung CD, Liao J, Liu B, "et al." |title=Specific inhibition of Stat3 signal transduction by PIAS3. |journal=Science |volume=278 |issue= 5344 |pages= 1803–5 |year= 1997 |pmid= 9388184 |doi=
*cite journal | author=Ueki N, Seki N, Yano K, "et al." |title=Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). |journal=J. Hum. Genet. |volume=44 |issue= 3 |pages= 193–6 |year= 1999 |pmid= 10319586 |doi=
*cite journal | author=Rödel B, Tavassoli K, Karsunky H, "et al." |title=The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5845–55 |year= 2000 |pmid= 11060035 |doi= 10.1093/emboj/19.21.5845
*cite journal | author=Junicho A, Matsuda T, Yamamoto T, "et al." |title=Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 1 |pages= 9–13 |year= 2001 |pmid= 11071847 |doi= 10.1006/bbrc.2000.3753
*cite journal | author=Kotaja N, Aittomäki S, Silvennoinen O, "et al." |title=ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. |journal=Mol. Endocrinol. |volume=14 |issue= 12 |pages= 1986–2000 |year= 2001 |pmid= 11117529 |doi=
*cite journal | author=Zentner MD, Lin HH, Deng HT, "et al." |title=Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29805–14 |year= 2001 |pmid= 11390395 |doi= 10.1074/jbc.M103153200
*cite journal | author=Wang LH, Yang XY, Mihalic K, "et al." |title=Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 31839–44 |year= 2001 |pmid= 11429412 |doi= 10.1074/jbc.M105185200
*cite journal | author=Levy C, Nechushtan H, Razin E |title=A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1962–6 |year= 2002 |pmid= 11709556 |doi= 10.1074/jbc.M109236200
*cite journal | author=Jiménez-Lara AM, Heine MJ, Gronemeyer H |title=PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2. |journal=FEBS Lett. |volume=526 |issue= 1-3 |pages= 142–6 |year= 2002 |pmid= 12208521 |doi=
*cite journal | author=Nakagawa K, Yokosawa H |title=PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1. |journal=FEBS Lett. |volume=530 |issue= 1-3 |pages= 204–8 |year= 2002 |pmid= 12387893 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yamamoto T, Sato N, Sekine Y, "et al." |title=Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 2 |pages= 610–5 |year= 2003 |pmid= 12804609 |doi=
*cite journal | author=Di Y, Li J, Zhang Y, "et al." |title=HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. |journal=J. Biochem. |volume=133 |issue= 6 |pages= 713–8 |year= 2004 |pmid= 12869526 |doi=
*cite journal | author=Cheng J, Zhang D, Zhou C, Marasco WA |title=Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells. |journal=Leuk. Res. |volume=28 |issue= 1 |pages= 71–82 |year= 2004 |pmid= 14630083 |doi=
*cite journal | author=Long J, Wang G, Matsuura I, "et al." |title=Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 1 |pages= 99–104 |year= 2004 |pmid= 14691252 |doi= 10.1073/pnas.0307598100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Nojiri S, Joh T, Miura Y, "et al." |title=ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 1 |pages= 97–103 |year= 2004 |pmid= 14715251 |doi=
*cite journal | author=Wang L, Banerjee S |title=Differential PIAS3 expression in human malignancy. |journal=Oncol. Rep. |volume=11 |issue= 6 |pages= 1319–24 |year= 2004 |pmid= 15138572 |doi=
*cite journal | author=Jang HD, Yoon K, Shin YJ, "et al." |title=PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24873–80 |year= 2004 |pmid= 15140884 |doi= 10.1074/jbc.M313018200
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104

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