Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, also known as SEMA3A, is a human gene.cite web | title = Entrez Gene: SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A| url =| accessdate = ]

section_title =
summary_text = This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.cite web | title = Entrez Gene: SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Schmidt EF, Strittmatter SM |title=The CRMP family of proteins and their role in Sema3A signaling. |journal=Adv. Exp. Med. Biol. |volume=600 |issue= |pages= 1–11 |year= 2007 |pmid= 17607942 |doi=
*cite journal | author=Püschel AW, Adams RH, Betz H |title=Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. |journal=Neuron |volume=14 |issue= 5 |pages= 941–8 |year= 1995 |pmid= 7748561 |doi=
*cite journal | author=Kolodkin AL, Matthes DJ, Goodman CS |title=The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. |journal=Cell |volume=75 |issue= 7 |pages= 1389–99 |year= 1994 |pmid= 8269517 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Chen H, Chédotal A, He Z, "et al." |title=Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. |journal=Neuron |volume=19 |issue= 3 |pages= 547–59 |year= 1997 |pmid= 9331348 |doi=
*cite journal | author=Takahashi T, Nakamura F, Jin Z, "et al." |title=Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. |journal=Nat. Neurosci. |volume=1 |issue= 6 |pages= 487–93 |year= 1999 |pmid= 10196546 |doi= 10.1038/2203
*cite journal | author=Takahashi T, Fournier A, Nakamura F, "et al." |title=Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. |journal=Cell |volume=99 |issue= 1 |pages= 59–69 |year= 1999 |pmid= 10520994 |doi=
*cite journal | author=Castellani V, De Angelis E, Kenwrick S, Rougon G |title=Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A. |journal=EMBO J. |volume=21 |issue= 23 |pages= 6348–57 |year= 2003 |pmid= 12456642 |doi=
*cite journal | author=Eastwood SL, Law AJ, Everall IP, Harrison PJ |title=The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology. |journal=Mol. Psychiatry |volume=8 |issue= 2 |pages= 148–55 |year= 2003 |pmid= 12610647 |doi= 10.1038/
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Rieger J, Wick W, Weller M |title=Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins. |journal=Glia |volume=42 |issue= 4 |pages= 379–89 |year= 2003 |pmid= 12730958 |doi= 10.1002/glia.10210
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Serini G, Valdembri D, Zanivan S, "et al." |title=Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. |journal=Nature |volume=424 |issue= 6947 |pages= 391–7 |year= 2003 |pmid= 12879061 |doi= 10.1038/nature01784
*cite journal | author=Bachelder RE, Lipscomb EA, Lin X, "et al." |title=Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. |journal=Cancer Res. |volume=63 |issue= 17 |pages= 5230–3 |year= 2003 |pmid= 14500350 |doi=
*cite journal | author=Catalano A, Caprari P, Rodilossi S, "et al." |title=Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation. |journal=FASEB J. |volume=18 |issue= 2 |pages= 358–60 |year= 2004 |pmid= 14656993 |doi= 10.1096/fj.03-0513fje
*cite journal | author=Bagnard D, Sainturet N, Meyronet D, "et al." |title=Differential MAP kinases activation during semaphorin3A-induced repulsion or apoptosis of neural progenitor cells. |journal=Mol. Cell. Neurosci. |volume=25 |issue= 4 |pages= 722–31 |year= 2004 |pmid= 15080899 |doi= 10.1016/j.mcn.2003.12.007
*cite journal | author=Good PF, Alapat D, Hsu A, "et al." |title=A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease. |journal=J. Neurochem. |volume=91 |issue= 3 |pages= 716–36 |year= 2005 |pmid= 15485501 |doi= 10.1111/j.1471-4159.2004.02766.x
*cite journal | author=Marzioni D, Tamagnone L, Capparuccia L, "et al." |title=Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A. |journal=Dev. Dyn. |volume=231 |issue= 4 |pages= 839–48 |year= 2005 |pmid= 15517571 |doi= 10.1002/dvdy.20178
*cite journal | author=Gu C, Yoshida Y, Livet J, "et al." |title=Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. |journal=Science |volume=307 |issue= 5707 |pages= 265–8 |year= 2005 |pmid= 15550623 |doi= 10.1126/science.1105416
*cite journal | author=Kashiwagi H, Shiraga M, Kato H, "et al." |title=Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A. |journal=Blood |volume=106 |issue= 3 |pages= 913–21 |year= 2005 |pmid= 15831706 |doi= 10.1182/blood-2004-10-4092

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