- DPYSL5
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Dihydropyrimidinase-like 5 Identifiers Symbols DPYSL5; CRAM; CRMP-5; CRMP5; FLJ45383; Ulip6 External IDs OMIM: 608383 MGI: 1929772 HomoloGene: 41347 GeneCards: DPYSL5 Gene Gene Ontology Molecular function • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Cellular component • cytoplasm
• cytosol
• dendrite
• neuronal cell body
• protein complexBiological process • pyrimidine base catabolic process
• signal transduction
• nervous system development
• axon guidance
• neuron differentiationSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 56896 65254 Ensembl ENSG00000157851 ENSMUSG00000029168 UniProt Q9BPU6 Q9EQF6 RefSeq (mRNA) NM_020134 NM_023047.2 RefSeq (protein) NP_064519 NP_075534.1 Location (UCSC) Chr 2:
27.07 – 27.17 MbChr 5:
31.01 – 31.1 MbPubMed search [1] [2] Dihydropyrimidinase-related protein 5 is an enzyme that in humans is encoded by the DPYSL5 gene.[1][2][3]
Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.[supplied by OMIM][3]
References
- ^ Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
- ^ Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett 480 (2-3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345.
- ^ a b "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56896.
Further reading
- Cross SA, Salomao DR, Parisi JE, et al. (2003). "Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG.". Ann. Neurol. 54 (1): 38–50. doi:10.1002/ana.10587. PMID 12838519.
- Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family.". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
- Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity.". Ann. Neurol. 49 (2): 146–54. doi:10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E. PMID 11220734.
- Ricard D, Rogemond V, Charrier E, et al. (2001). "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes.". J. Neurosci. 21 (18): 7203–14. PMID 11549731.
- Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125392.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Categories:- Human proteins
- Chromosome 2 gene stubs
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