DHX9

DEAH (Asp-Glu-Ala-His) box polypeptide 9, also known as DHX9, is a human gene.cite web | title = Entrez Gene: DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1660| accessdate = ]

PBB_Summary
section_title =
summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity.cite web | title = Entrez Gene: DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1660| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee CG, Hurwitz J |title=A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction. |journal=J. Biol. Chem. |volume=267 |issue= 7 |pages= 4398–407 |year= 1992 |pmid= 1537828 |doi=
*cite journal | author=Lee CG, Zamore PD, Green MR, Hurwitz J |title=RNA annealing activity is intrinsically associated with U2AF. |journal=J. Biol. Chem. |volume=268 |issue= 18 |pages= 13472–8 |year= 1993 |pmid= 7685763 |doi=
*cite journal | author=Lee CG, Hurwitz J |title=Human RNA helicase A is homologous to the maleless protein of Drosophila. |journal=J. Biol. Chem. |volume=268 |issue= 22 |pages= 16822–30 |year= 1993 |pmid= 8344961 |doi=
*cite journal | author=Abdelhaleem MM, Hameed S, Klassen D, Greenberg AH |title=Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. |journal=J. Immunol. |volume=156 |issue= 6 |pages= 2026–35 |year= 1996 |pmid= 8690889 |doi=
*cite journal | author=Zhang S, Grosse F |title=Domain structure of human nuclear DNA helicase II (RNA helicase A). |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11487–94 |year= 1997 |pmid= 9111062 |doi=
*cite journal | author=Nakajima T, Uchida C, Anderson SF, "et al." |title=RNA helicase A mediates association of CBP with RNA polymerase II. |journal=Cell |volume=90 |issue= 6 |pages= 1107–12 |year= 1997 |pmid= 9323138 |doi=
*cite journal | author=Loor G, Zhang SJ, Zhang P, "et al." |title=Identification of DNA replication and cell cycle proteins that interact with PCNA. |journal=Nucleic Acids Res. |volume=25 |issue= 24 |pages= 5041–6 |year= 1998 |pmid= 9396813 |doi=
*cite journal | author=Lee CG, Eki T, Okumura K, "et al." |title=Molecular analysis of the cDNA and genomic DNA encoding mouse RNA helicase A. |journal=Genomics |volume=47 |issue= 3 |pages= 365–71 |year= 1998 |pmid= 9480750 |doi=
*cite journal | author=Anderson SF, Schlegel BP, Nakajima T, "et al." |title=BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. |journal=Nat. Genet. |volume=19 |issue= 3 |pages= 254–6 |year= 1998 |pmid= 9662397 |doi= 10.1038/930
*cite journal | author=Lee CG, da Costa Soares V, Newberger C, "et al." |title=RNA helicase A is essential for normal gastrulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13709–13 |year= 1998 |pmid= 9811865 |doi=
*cite journal | author=Li J, Tang H, Mullen TM, "et al." |title=A role for RNA helicase A in post-transcriptional regulation of HIV type 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 709–14 |year= 1999 |pmid= 9892698 |doi=
*cite journal | author=Tang H, McDonald D, Middlesworth T, "et al." |title=The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3540–50 |year= 1999 |pmid= 10207077 |doi=
*cite journal | author=Westberg C, Yang JP, Tang H, "et al." |title=A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21396–401 |year= 2000 |pmid= 10748171 |doi= 10.1074/jbc.M909887199
*cite journal | author=Tang H, Wong-Staal F |title=Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32694–700 |year= 2000 |pmid= 10924507 |doi= 10.1074/jbc.M003933200
*cite journal | author=Lee CG, Eki T, Okumura K, "et al." |title=The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively. |journal=Somat. Cell Mol. Genet. |volume=25 |issue= 1 |pages= 33–9 |year= 2000 |pmid= 10925702 |doi=
*cite journal | author=Reddy TR, Tang H, Xu W, Wong-Staal F |title=Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA. |journal=Oncogene |volume=19 |issue= 32 |pages= 3570–5 |year= 2000 |pmid= 10951562 |doi= 10.1038/sj.onc.1203676
*cite journal | author=Pellizzoni L, Charroux B, Rappsilber J, "et al." |title=A functional interaction between the survival motor neuron complex and RNA polymerase II. |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 75–85 |year= 2001 |pmid= 11149922 |doi=
*cite journal | author=Takasaki Y, Kogure T, Takeuchi K, "et al." |title=Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation. |journal=J. Immunol. |volume=166 |issue= 7 |pages= 4780–7 |year= 2001 |pmid= 11254741 |doi=
*cite journal | author=Yang JP, Tang H, Reddy TR, Wong-Staal F |title=Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 30694–700 |year= 2001 |pmid= 11402034 |doi= 10.1074/jbc.M102809200
*cite journal | author=Aratani S, Fujii R, Oishi T, "et al." |title=Dual roles of RNA helicase A in CREB-dependent transcription. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4460–9 |year= 2001 |pmid= 11416126 |doi= 10.1128/MCB.21.14.4460-4469.2001

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