Coxsackie virus and adenovirus receptor

Coxsackie virus and adenovirus receptor
Coxsackie virus and adenovirus receptor

PDB rendering based on 1eaj.
Symbols CXADR; CAR; CAR4/6; HCAR
External IDs OMIM602621 MGI1201679 HomoloGene1024 GeneCards: CXADR Gene
RNA expression pattern
PBB GE CXADR 203917 at tn.png
More reference expression data
Species Human Mouse
Entrez 1525 13052
Ensembl ENSG00000154639 ENSMUSG00000022865
UniProt P78310 Q3TV22
RefSeq (mRNA) NM_001207063.1 NM_001025192
RefSeq (protein) NP_001193992.1 NP_001020363
Location (UCSC) Chr 21:
18.88 – 18.97 Mb
Chr 16:
78.3 – 78.36 Mb
PubMed search [1] [2]

Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene.[1][2][3] The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.[3]


CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R.[4]


  1. ^ Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Mar 1997). "Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5". Science 275 (5304): 1320–3. doi:10.1126/science.275.5304.1320. PMID 9036860. 
  2. ^ Tomko RP, Xu R, Philipson L (May 1997). "HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses". Proc Natl Acad Sci U S A 94 (7): 3352–6. doi:10.1073/pnas.94.7.3352. PMC 20373. PMID 9096397. 
  3. ^ a b "Entrez Gene: CXADR coxsackie virus and adenovirus receptor". 
  4. ^ Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG (Feb 2010). "The Coxsackievirus-Adenovirus Receptor reveals complex homophilic and heterophilic interactions on neural cells". Journal of Neuroscience 30 (8): 2897–2910. doi:10.1523/JNEUROSCI.5725-09.2010. PMID 20181587. 

Further reading

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