HDAC1

Histone deacetylase 1, also known as HDAC1, is a human gene.

PBB_Summary
section_title =
summary_text = Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.cite web | title = Entrez Gene: HDAC1 histone deacetylase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3065| accessdate = ]

ee also

* Histone deacetylase
* Histone deacetylase inhibitor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wolffe AP |title=Histone deacetylase: a regulator of transcription. |journal=Science |volume=272 |issue= 5260 |pages= 371–2 |year= 1996 |pmid= 8602525 |doi=
*cite journal | author=Ahringer J |title=NuRD and SIN3 histone deacetylase complexes in development. |journal=Trends Genet. |volume=16 |issue= 8 |pages= 351–6 |year= 2000 |pmid= 10904264 |doi=
*cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286–93 |year= 2003 |pmid= 12711221 |doi=
*cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401–14 |year= 2003 |pmid= 12943729 |doi=
*cite journal | author=Stevens M, De Clercq E, Balzarini J |title=The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. |journal=Med Res Rev |volume=26 |issue= 5 |pages= 595–625 |year= 2007 |pmid= 16838299 |doi= 10.1002/med.20081
*cite journal | author=Hijmans EM, Voorhoeve PM, Beijersbergen RL, "et al." |title=E2F-5, a new E2F family member that interacts with p130 in vivo. |journal=Mol. Cell. Biol. |volume=15 |issue= 6 |pages= 3082–9 |year= 1995 |pmid= 7760804 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Margolis DM, Somasundaran M, Green MR |title=Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production. |journal=J. Virol. |volume=68 |issue= 2 |pages= 905–10 |year= 1994 |pmid= 8289393 |doi=
*cite journal | author=Taunton J, Hassig CA, Schreiber SL |title=A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. |journal=Science |volume=272 |issue= 5260 |pages= 408–11 |year= 1996 |pmid= 8602529 |doi=
*cite journal | author=Furukawa Y, Kawakami T, Sudo K, "et al." |title=Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 130–3 |year= 1996 |pmid= 8646880 |doi=
*cite journal | author=Hassig CA, Fleischer TC, Billin AN, "et al." |title=Histone deacetylase activity is required for full transcriptional repression by mSin3A. |journal=Cell |volume=89 |issue= 3 |pages= 341–7 |year= 1997 |pmid= 9150133 |doi=
*cite journal | author=Laherty CD, Yang WM, Sun JM, "et al." |title=Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. |journal=Cell |volume=89 |issue= 3 |pages= 349–56 |year= 1997 |pmid= 9150134 |doi=
*cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, "et al." |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=
*cite journal | author=Romerio F, Gabriel MN, Margolis DM |title=Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9375–82 |year= 1997 |pmid= 9371597 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Brehm A, Miska EA, McCance DJ, "et al." |title=Retinoblastoma protein recruits histone deacetylase to repress transcription. |journal=Nature |volume=391 |issue= 6667 |pages= 597–601 |year= 1998 |pmid= 9468139 |doi= 10.1038/35404
*cite journal | author=Magnaghi-Jaulin L, Groisman R, Naguibneva I, "et al." |title=Retinoblastoma protein represses transcription by recruiting a histone deacetylase. |journal=Nature |volume=391 |issue= 6667 |pages= 601–5 |year= 1998 |pmid= 9468140 |doi= 10.1038/35410
*cite journal | author=Lin RJ, Nagy L, Inoue S, "et al." |title=Role of the histone deacetylase complex in acute promyelocytic leukaemia. |journal=Nature |volume=391 |issue= 6669 |pages= 811–4 |year= 1998 |pmid= 9486654 |doi= 10.1038/35895
*cite journal | author=Luo RX, Postigo AA, Dean DC |title=Rb interacts with histone deacetylase to repress transcription. |journal=Cell |volume=92 |issue= 4 |pages= 463–73 |year= 1998 |pmid= 9491888 |doi=

External links

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