Nuclear receptor co-repressor 2

Nuclear receptor co-repressor 2
Nuclear receptor corepressor 2

PDB rendering based on 1xc5.
Identifiers
Symbols NCOR2; CTG26; FLJ25011; N-CoR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1
External IDs OMIM600848 MGI1337080 HomoloGene31370 GeneCards: NCOR2 Gene
RNA expression pattern
PBB GE NCOR2 207760 s at tn.png
PBB GE NCOR2 208888 s at tn.png
PBB GE NCOR2 208889 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9612 20602
Ensembl ENSG00000196498 ENSMUSG00000029478
UniProt Q9Y618 n/a
RefSeq (mRNA) NM_001077261.3 NM_011424.2
RefSeq (protein) NP_001070729.2 NP_035554.2
Location (UCSC) Chr 12:
124.81 – 125.05 Mb
Chr 5:
125.5 – 125.66 Mb
PubMed search [1] [2]

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[1][2] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[1] or T3 receptor-associating cofactor 1 (TRAC-1).[2]

Contents

Function

NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.[1] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[3]

Discovery

SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[1] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[2]

Interactions

Nuclear receptor co-repressor 2 has been shown to interact with Thyroid hormone receptor beta,[4][5][6] Retinoic acid receptor alpha,[7][8] HDAC1,[9][10] Nerve Growth factor IB,[11] Zinc finger and BTB domain-containing protein 16,[8][12][13] SIN3A,[14][15] BCL6,[13][16][17] SNW1,[18][19] Androgen receptor,[20][21][22] Peroxisome proliferator-activated receptor delta,[23] C-Fos,[24] POU2F1,[25] Histone deacetylase 5,[15] HDAC10,[9] RELA,[24][26] RBPJ,[27][28] TBL1X,[14][29][30][31] RUNX1T1,[12][32] HDAC4,[15][33] Progesterone receptor,[34] HDAC3,[10][14][29][30][31][33][35] SPEN,[36] Serum response factor,[24] C-jun,[24] Calcitriol receptor[5][37] and Promyelocytic leukemia protein.[38][39]

References

  1. ^ a b c d Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127. 
  2. ^ a b c Sande S, Privalsky ML (1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Mol Endocrinol 10 (7): 813–25. doi:10.1210/me.10.7.813. PMID 8813722. 
  3. ^ Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM (1997). "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase". Cell 89 (3): 373–80. doi:10.1016/S0092-8674(00)80218-4. PMID 9150137. 
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