TBL1X

Transducin (beta)-like 1X-linked, also known as TBL1X, is a human gene.cite web | title = Entrez Gene: TBL1X transducin (beta)-like 1X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6907| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.cite web | title = Entrez Gene: TBL1X transducin (beta)-like 1X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6907| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bassi MT, Ramesar RS, Caciotti B, "et al." |title=X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. |journal=Am. J. Hum. Genet. |volume=64 |issue= 6 |pages= 1604–16 |year= 1999 |pmid= 10330347 |doi=
*cite journal | author=Guenther MG, Lane WS, Fischle W, "et al." |title=A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. |journal=Genes Dev. |volume=14 |issue= 9 |pages= 1048–57 |year= 2000 |pmid= 10809664 |doi=
*cite journal | author=Li J, Wang J, Wang J, "et al." |title=Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4342–50 |year= 2000 |pmid= 10944117 |doi= 10.1093/emboj/19.16.4342
*cite journal | author=Matsuzawa SI, Reed JC |title=Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 915–26 |year= 2001 |pmid= 11389839 |doi=
*cite journal | author=Zhang J, Kalkum M, Chait BT, Roeder RG |title=The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 611–23 |year= 2002 |pmid= 11931768 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yoon HG, Chan DW, Huang ZQ, "et al." |title=Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1336–46 |year= 2003 |pmid= 12628926 |doi= 10.1093/emboj/cdg120
*cite journal | author=Yoon HG, Chan DW, Reynolds AB, "et al." |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723–34 |year= 2003 |pmid= 14527417 |doi=
*cite journal | author=Perissi V, Aggarwal A, Glass CK, "et al." |title=A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. |journal=Cell |volume=116 |issue= 4 |pages= 511–26 |year= 2004 |pmid= 14980219 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yoon HG, Choi Y, Cole PA, Wong J |title=Reading and function of a histone code involved in targeting corepressor complexes for repression. |journal=Mol. Cell. Biol. |volume=25 |issue= 1 |pages= 324–35 |year= 2005 |pmid= 15601853 |doi= 10.1128/MCB.25.1.324-335.2005
*cite journal | author=Gerlitz G, Darhin E, Giorgio G, "et al." |title=Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1632–40 |year= 2005 |pmid= 16258276 |doi=

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