Nuclear receptor co-repressor 1

Nuclear receptor co-repressor 1
Nuclear receptor corepressor 1

Rendering based on PDB 2EQR.
Symbols NCOR1; KIAA1047; MGC104216; N-CoR; N-CoR1; TRAC1; hN-CoR
External IDs OMIM600849 MGI1349717 HomoloGene38166 GeneCards: NCOR1 Gene
RNA expression pattern
PBB GE NCOR1 200854 at tn.png
PBB GE NCOR1 200855 at tn.png
PBB GE NCOR1 200856 x at tn.png
More reference expression data
Species Human Mouse
Entrez 9611 20185
Ensembl ENSG00000141027 ENSMUSG00000018501
UniProt O75376 n/a
RefSeq (mRNA) NM_001190438.1 NM_011308.2
RefSeq (protein) NP_001177367.1 NP_035438.2
Location (UCSC) Chr 17:
15.93 – 16.12 Mb
Chr 11:
62.13 – 62.27 Mb
PubMed search [1] [2]

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.[1][2]

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.[1][3]

Loss of function of this protein significantly increases the strength and power of mouse muscles.[4]



Nuclear receptor co-repressor 1 has been shown to interact with HDAC9,[5] CHD1,[6] HDAC7A,[7] MAP3K7IP2,[8] Glucocorticoid receptor,[9][10] MECP2,[11] Peroxisome proliferator-activated receptor alpha,[12] HEY2,[13] Histone deacetylase 5,[14][15] TBL1XR1,[14][16][17] TBL1X,[14][17][18][19] HDAC3,[7][14][16][17][18][20][21] ZBTB33,[16] Retinoic acid receptor alpha,[12][22] SAP30,[21][23] Androgen receptor,[24][25][26][27] Retinoic acid receptor gamma,[12] RUNX1T1,[28][29] HDAC4,[15][20] GPS2,[14][16][17] Calcitriol receptor[30][31] and Promyelocytic leukemia protein.[32]


  1. ^ a b Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK (October 1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114. 
  2. ^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (September 1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. PMC 27986. PMID 9724795. 
  3. ^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA 95 (18): 10860–5. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795. 
  4. ^ Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans E, Auwerx J (2011). "NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function". Cell 147 (4): 827–839. 
  5. ^ Petrie, Kevin; Guidez Fabien, Howell Louise, Healy Lyn, Waxman Samuel, Greaves Mel, Zelent Arthur (May. 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem. (United States) 278 (18): 16059–72. doi:10.1074/jbc.M212935200. ISSN 0021-9258. PMID 12590135. 
  6. ^ Tai, Helen H; Geisterfer Margit, Bell John C, Moniwa Mariko, Davie James R, Boucher Lorrie, McBurney Michael W (Aug. 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. (United States) 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. ISSN 0006-291X. PMID 12890497. 
  7. ^ a b Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. (United States) 276 (38): 35826–35. doi:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315. 
  8. ^ Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell (United States) 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. ISSN 0092-8674. PMID 12150997. 
  9. ^ Stevens, Adam; Garside Helen, Berry Andrew, Waters Charlotte, White Anne, Ray David (May. 2003). "Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735". Mol. Endocrinol. (United States) 17 (5): 845–59. doi:10.1210/me.2002-0320. ISSN 0888-8809. PMID 12569182. 
  10. ^ Schulz, Martin; Eggert Martin, Baniahmad Aria, Dostert Anja, Heinzel Thorsten, Renkawitz Rainer (Jul. 2002). "RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding". J. Biol. Chem. (United States) 277 (29): 26238–43. doi:10.1074/jbc.M203268200. ISSN 0021-9258. PMID 12011091. 
  11. ^ Kokura, K; Kaul S C, Wadhwa R, Nomura T, Khan M M, Shinagawa T, Yasukawa T, Colmenares C, Ishii S (Sep. 2001). "The Ski protein family is required for MeCP2-mediated transcriptional repression". J. Biol. Chem. (United States) 276 (36): 34115–21. doi:10.1074/jbc.M105747200. ISSN 0021-9258. PMID 11441023. 
  12. ^ a b c Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May. 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. (UNITED STATES) 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. ISSN 0021-9258. PMID 10336495. 
  13. ^ Iso, T; Sartorelli V, Poizat C, Iezzi S, Wu H Y, Chung G, Kedes L, Hamamori Y (Sep. 2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. (United States) 21 (17): 6080–9. doi:10.1128/MCB.21.17.6080-6089.2001. ISSN 0270-7306. PMC 87325. PMID 11486045. 
  14. ^ a b c d e Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell (United States) 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. ISSN 1097-2765. PMID 11931768. 
  15. ^ a b Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A (Jan. 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. (UNITED STATES) 14 (1): 45–54. ISSN 0890-9369. PMC 316335. PMID 10640275. 
  16. ^ a b c d Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell (United States) 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. ISSN 1097-2765. PMID 14527417. 
  17. ^ a b c d Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. (England) 22 (6): 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMC 151047. PMID 12628926. 
  18. ^ a b Li, J; Wang J, Wang J, Nawaz Z, Liu J M, Qin J, Wong J (Aug. 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. (ENGLAND) 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. ISSN 0261-4189. PMC 302030. PMID 10944117. 
  19. ^ Guenther, M G; Lane W S, Fischle W, Verdin E, Lazar M A, Shiekhattar R (May. 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. (UNITED STATES) 14 (9): 1048–57. ISSN 0890-9369. PMC 316569. PMID 10809664. 
  20. ^ a b Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell (United States) 9 (1): 45–57. doi:10.1016/S1097-2765(01)00429-4. ISSN 1097-2765. PMID 11804585. 
  21. ^ a b Underhill, C; Qutob M S, Yee S P, Torchia J (Dec. 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem. (UNITED STATES) 275 (51): 40463–70. doi:10.1074/jbc.M007864200. ISSN 0021-9258. PMID 11013263. 
  22. ^ Guidez, F; Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (Apr. 1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood (UNITED STATES) 91 (8): 2634–42. ISSN 0006-4971. PMID 9531570. 
  23. ^ Laherty, C D; Billin A N, Lavinsky R M, Yochum G S, Bush A C, Sun J M, Mullen T M, Davie J R, Rose D W, Glass C K, Rosenfeld M G, Ayer D E, Eisenman R N (Jul. 1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell (UNITED STATES) 2 (1): 33–42. doi:10.1016/S1097-2765(00)80111-2. ISSN 1097-2765. PMID 9702189. 
  24. ^ Masiello, David; Chen Shao-Yong, Xu Youyuan, Verhoeven Manon C, Choi Eunis, Hollenberg Anthony N, Balk Steven P (Oct. 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Mol. Endocrinol. (United States) 18 (10): 2388–401. doi:10.1210/me.2003-0436. ISSN 0888-8809. PMID 15256534. 
  25. ^ Song, Liang-Nian; Coghlan Meghan, Gelmann Edward P (Jan. 2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. (United States) 18 (1): 70–85. doi:10.1210/me.2003-0189. ISSN 0888-8809. PMID 14593076. 
  26. ^ Cheng, Shinta; Brzostek Sabrina, Lee Suzanne R, Hollenberg Anthony N, Balk Steven P (Jul. 2002). "Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor". Mol. Endocrinol. (United States) 16 (7): 1492–501. doi:10.1210/me.16.7.1492. ISSN 0888-8809. PMID 12089345. 
  27. ^ Hodgson, Myles C; Astapova Inna, Cheng Shinta, Lee Larissa J, Verhoeven Manon C, Choi Eunis, Balk Steven P, Hollenberg Anthony N (Feb. 2005). "The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists". J. Biol. Chem. (United States) 280 (8): 6511–9. doi:10.1074/jbc.M408972200. ISSN 0021-9258. PMID 15598662. 
  28. ^ Amann, J M; Nip J, Strom D K, Lutterbach B, Harada H, Lenny N, Downing J R, Meyers S, Hiebert S W (Oct. 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. (United States) 21 (19): 6470–83. doi:10.1128/MCB.21.19.6470-6483.2001. ISSN 0270-7306. PMC 99794. PMID 11533236. 
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