PELP-1

proline, glutamic acid and leucine rich protein 1
Identifiers
Symbol	PELP1
Entrez	27043
HUGO	30134
OMIM	609455
RefSeq	NM_014389
UniProt	Q8IZL8
Other data
Locus	Chr. 17 p13.2

PELP-1 (MNAR)^[1] is a transcriptional corepressor for nuclear receptors such as glucocorticoid receptors^[2] and a coactivator for estrogen receptors.^[3]

Activation of protein kinases

PELP-1 has been shown to bind to both estrogen receptor alpha and estrogen receptor beta.^[3] It was also reported that protein tyrosine kinases of the src family can form a complex with estrogen receptors and PELP-1 and it was reported that when bound to PELP-1 and estrogen receptor alpha the kinase activity of SRC was activated in an estrogen-sensitive manner. Mitogen-activated protein kinases ERK1 and ERK2 were found to become phosphorylated in estrogen-treated cells containing PELP-1 . It was reported that the enhancement of estrogen-induced gene transcription due to PELP-1 could be blocked by protein kinase inhibitors. This suggested a model of PELP-1 function in which estrogen and PELP-1 cooperate to activate protein kinases which in turn activate gene transcription.

Histone deacetylase

When functioning as a corepressor of transcription PELP-1 recruits histone deacetylase.^[2] Estrogen has been associated with stimulation of cell proliferation and progression of cells through G₁ to the S phase of the cell cycle. The retinoblastoma protein (Rb) is a regulator of G₁. It was reported that PELP-1 interacts with Rb.^[4] It is not known if estrogen receptors can displace histone deacetylase from Rb.

See also

• Transcription coregulator

External links

• MeSH protein, human/MB_cgi?mode=&term=PELP1+protein,+human PELP1+protein,+human
• {{NURSA}C9}}

References

1. ^ Vadlamudi RK, Kumar R (2007). "Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR". Nuclear receptor signaling 5: e004. doi:10.1621/nrs.05004. PMC 1876599. PMID 17525794. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1876599. 
2. ^ ^{a b} Choi YB, Ko JK, Shin J (December 2004). "The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains". J. Biol. Chem. 279 (49): 50930–41. doi:10.1074/jbc.M406831200. PMID 15456770. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=15456770. 
3. ^ ^{a b} Vadlamudi RK, Wang RA, Mazumdar A, et al. (October 2001). "Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha". J. Biol. Chem. 276 (41): 38272–9. doi:10.1074/jbc.M103783200. PMID 11481323. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11481323. 
4. ^ Balasenthil S, Vadlamudi RK (June 2003). "Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein". J. Biol. Chem. 278 (24): 22119–27. doi:10.1074/jbc.M212822200. PMC 1262660. PMID 12682072. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=12682072.